Characteristic evaluation of the thermal neutron irradiation field using a 30 MeV cyclotron accelerator for basic research on neutron capture therapy
Characteristic evaluation of the thermal neutron irradiation field using a 30 MeV cyclotron accelerator for basic research on neutron capture therapy
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DOI：
10.1016/j.nima.2020.164533
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发表时间：
2020-12-11
影响因子：
1.4
通讯作者：
Ono, K.
中科院分区：
文献类型：
--
作者：
Tanaka, H.;Takata, T.;Ono, K.
开发一种用于硼中子俘获治疗(BNCT)的新的硼化合物需要高强度的热中子束，并需要建造热中子场来取代计划在未来暂停的研究反应堆。将回旋加速器超热中子源与慢化器相结合，产生了一个热中子辐射场，并对其特性进行了评价。研究证实，当热中子强度为4.83×10(8)n cm(-2)时，可以充分照射小鼠的四肢。每热中子通量的中子剂量率和伽马射线剂量率分别为8.3×10(-13)和1.4×10(-12)Gycm2。此外，利用水模，获得了最大热中子通量为1.35×10(9)n cm(-2)S(-1)的辐照。在这种情况下，每热中子通量的中子剂量率和伽马射线剂量率分别为2.7×10(-13)和8.3×10(-13)Gycm2。成功地制造了一种能够照射小鼠和细胞的辐射场，并与目前使用的研究反应堆的辐射场进行了比较。
The development of a new boron compound for boron neutron capture therapy (BNCT) requires a high-intensity thermal neutron beam and the construction of thermal neutron fields in place of research reactors scheduled for suspension in the future. A thermal neutron irradiation field was produced by combining a cyclotron-based epithermal neutron source with a moderator to form an irradiation field for mice and cells, and its characteristics were evaluated.Our study confirmed that the lower limbs of the mouse could be sufficiently irradiated with a thermal neutron intensity of 4.83 x 10(8) n cm(-2) s(-1). The neutron dose rate and gamma ray dose rate per thermal neutron flux were 8.3 x 10(-13) and 1.4 x 10(-12) Gy cm(2), respectively. In addition, by using a water phantom, irradiation with a maximum thermal neutron flux of 1.35 x 10(9) n cm(-2) s(-1) was achieved. In this case, the neutron dose rate and gamma ray dose rate per thermal neutron flux were 2.7 x 10(-13) and 8.3 x 10(-13) Gy cm(2), respectively. An irradiation field capable of irradiating mice and cells was successfully produced and compared favorably with the irradiation fields from research reactors currently in use.