Path integration and lesions within the head direction cell circuit: Comparison between the roles of the anterodorsal thalamus and dorsal tegmental nucleus
Path integration and lesions within the head direction cell circuit: Comparison between the roles of the anterodorsal thalamus and dorsal tegmental nucleus
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DOI：
10.1037/0735-7044.120.1.135
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发表时间：
2006-02-01
影响因子：
1.9
通讯作者：
Taube, JS
中科院分区：
文献类型：
--
作者：
Frohardt, RJ;Bassett, JP;Taube, JS
本实验旨在研究丘脑前背核（ADN）和被盖背核（DTN）这两个头部方向细胞回路的两个区域是否参与导航。在接受假损伤或双侧ADN或DTN损伤之前，训练大鼠在有和没有眼罩的情况下执行食物搬运任务。在两个版本的任务中，ADN损伤的大鼠均轻度受损。然而，DTN损伤的大鼠，严重受损，并表现出降低标题的准确性，在两个任务版本。这些研究结果表明，虽然DTN和ADN有助于导航的基础上的路径整合和地标，中断的头方向细胞电路的水平DTN有一个显着更大的影响空间行为比病变的ADN。
Experiments were designed to determine whether 2 regions of the head direction cell circuit, the anterodorsal thalamic nucleus (ADN) and the dorsal tegmental nucleus (DTN), contribute to navigation. Rats were trained to perform a food-carrying task with and without blindfolds prior to receiving sham lesions or bilateral lesions of the ADN or DTN. ADN-lesioned rats were mildly impaired in both versions of the task. DTN-lesioned rats, however, were severely impaired and showed reduced heading accuracy in both task versions. These findings suggest that although both the DTN and ADN contribute to navigation based on path integration and landmarks, disruption of the head direction cell circuit at the level of the DTN has a significantly greater effect on spatial behavior than lesions of the ADN.