NEUROPEPTIDE NEURONAL EFFERENTS FROM THE BED NUCLEUS OF THE STRIA TERMINALIS AND CENTRAL AMYGDALOID NUCLEUS TO THE DORSAL VAGAL COMPLEX IN THE RAT
NEUROPEPTIDE NEURONAL EFFERENTS FROM THE BED NUCLEUS OF THE STRIA TERMINALIS AND CENTRAL AMYGDALOID NUCLEUS TO THE DORSAL VAGAL COMPLEX IN THE RAT
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DOI：
10.1002/cne.902620304
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发表时间：
1987-08-15
影响因子：
2.5
通讯作者：
MAGNUSON, DJ
中科院分区：
文献类型：
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作者：
GRAY, TS;MAGNUSON, DJ
终纹侧床核（BSTL）和杏仁核中央核（Ce）是大脑内具有类似传入和传出连接的杏仁核。先前的研究表明，这两个区域向背迷走神经复合体（背运动核和孤束核）发送轴突投射。本研究使用逆行荧光-免疫荧光联合方法检查参与该途径的细胞是否含有以下任何神经肽：促肾上腺皮质激素释放因子、神经紧张素、生长抑素、P物质、脑啡肽或丙氨酸。迷走神经背侧复合体的输入主要来自BSTL的腹侧和内侧，尽管BSTL的背侧和外侧也有相当数量的神经元。促肾上腺皮质激素释放因子、神经紧张素和生长抑素神经元主要位于BSTL背侧和Ce外侧，经迷走神经复合体注射后含有逆行示踪剂。BSTL腹侧和Ce内侧的P物质神经元向迷走背复合体提供稀疏输入。BSTL和Ce内的脑啡肽和丙氨酸神经元似乎没有投射到迷走背复合体。侧下丘脑内的促肾上腺皮质激素释放因子和神经紧张素神经元也投射到背迷走神经复合体。大约22%的Ce和15%的BSTL逆行标记的神经元是肽免疫反应途径的背腱复合体。然而，同样明显的是，在淀粉样迷走神经投射中，大多数假定的递质类型仍然未知。结果表明，BSTL的背侧和腹侧以及Ce的外侧和内侧在化学结构和连接方面是相同的区域。考虑到多肽在通往脑干的下行杏仁核通路中的可能功能，对数据进行了讨论。
The lateral bed nucleus of the stria terminalis (BSTL) and central nucleus of the amygdala (Ce) are amygdaloid nuclei that have similar afferent and efferent connections within the brain. Previous studies have demonstrated that both regions send axonal projections to the dorsal vagal complex (dorsal motor nucleus and nucleus tractus solitarii). The present study used the combined retrograde fluorescence-immunofluorescence method to examine whether cells contributing to this pathway contained any of the following neuropeptides: corticotropin-releasing factor, neurotensin, somatostatin, substance P, enkephalin, or galanin. The inputs to the dorsal vagal complex originated mainly from ventral BSTL and medial Ce, although a significant number of neurons within the dorsal BSTL and lateral Ce also contributed. Corticotropin-releasing factor, neurotensin, and somatostatin neurons mainly located within the dorsal BSTL and the lateral Ce contained retrograde tracer after injections into the vagal complex. Substance P neurons in the ventral BSTL and medial Ce provide a sparse input to the dorsal vagal complex. Enkephalin and galanin neurons within the BSTL and Ce did not appear to project to the dorsal vagal complex. Corticotropin-releasing factor and neurotensin neurons within the lateral hypothalamus also project to the dorsal vagal complex. Approximately 22% of the Ce and 15% of the BSTL retrogradely labeled neurons were peptide immunoreactive pathway to the dorsal fagal complex. However, it is also apparent that the majority of putative transmitter types within the amygadloid vagal projection still are unknown. The results suggest that the dorsal and ventral BSTL and the lateral and medial Ce, respectively, are homolgous zones with regard to chemoarchitecture and connections. The data is discussed considering the possible function of peptides within descending amygdaloid pathways to the brainstem.