Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: a diffusion tensor imaging (DTI) study.
Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: a diffusion tensor imaging (DTI) study.
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儿童创伤性脑损伤的神经认知和神经影像学相关性：弥散张量成像（DTI）研究。
DOI：
10.1016/j.acn.2007.03.004
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Lim,KelvinO
中科院分区：
文献类型：
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作者：
Wozniak,JeffreyR;Krach,Linda;Ward,Erin;Mueller,BryonA;Muetzel,Ryan;Schnoebelen,Sarah;Kiragu,Andrew;Lim,KelvinO
本研究探讨了弥散张量成像（DTI）对轻、中度小儿创伤性脑损伤（TBI）中微结构白色物质（WM）损伤的敏感性。14名TBI儿童和14名年龄在10-18岁的对照儿童在受伤后6-12个月进行了DTI扫描和神经认知评估。各组在智力上没有差异，但TBI儿童表现出较慢的处理速度，工作记忆和执行缺陷，以及更大的行为失调。TBI组在三个WM区域具有较低的各向异性分数（FA）：下额叶、上级额叶和胼胝体上。胼胝体无组间差异。额叶和胼胝体上区的FA与执行功能相关。胼胝体上FA也与运动速度相关。行为评分与胼胝体上FA相关。父母报告的执行缺陷与FA呈负相关。结果表明，DTI的措施是敏感的长期WM的变化，并与认知功能的儿童TBI。
This study examined the sensitivity of diffusion tensor imaging (DTI) to microstructural white matter (WM) damage in mild and moderate pediatric traumatic brain injury (TBI). Fourteen children with TBI and 14 controls ages 10–18 had DTI scans and neurocognitive evaluations at 6–12 months post-injury. Groups did not differ in intelligence, but children with TBI showed slower processing speed, working memory and executive deficits, and greater behavioral dysregulation. The TBI group had lower fractional anisotropy (FA) in three WM regions: inferior frontal, superior frontal, and supracallosal. There were no group differences in corpus callosum. FA in the frontal and supracallosal regions was correlated with executive functioning. Supracallosal FA was also correlated with motor speed. Behavior ratings showed correlations with supracallosal FA. Parent-reported executive deficits were inversely correlated with FA. Results suggest that DTI measures are sensitive to long-term WM changes and associated with cognitive functioning following pediatric TBI.