Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells.
Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells.
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DOI：
10.1111/aji.12623
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Aronoff DM
中科院分区：
文献类型：
--
作者：
Anders AP;Gaddy JA;Doster RS;Aronoff DM
绒毛膜羊膜炎是妊娠（胎盘外）膜的急性炎症，最常见的是由上升微生物感染引起的。它与新生儿不良结局相关，包括早产、新生儿败血症和脑瘫。蜕膜是妊娠膜的最外层，可能是上升感染过程中与微生物接触的重要起始部位。然而，关于蜕质细胞（DSCs）如何应对微生物威胁，我们知之甚少。确定单个细胞类型对绒毛膜羊膜炎期间炎症信号的复杂混合的贡献可能导致改善旨在阻止这种疾病的干预措施。我们回顾了现有的已发表的支持dsc在应对微生物感染中的作用的数据，特别关注它们的模式识别受体的表达和它们对病原体感知的反应性的证据。虽然在绒毛膜羊膜炎发病过程中，dsc可能在感知和响应感染方面发挥重要作用，但强调了重要的知识空白和未来研究的领域。
Chorioamnionitis is an acute inflammation of the gestational (extraplacental) membranes, most commonly caused by ascending microbial infection. It is associated with adverse neonatal outcomes including preterm birth, neonatal sepsis and cerebral palsy. The decidua is the outermost layer of the gestational membranes and is likely an important initial site of contact with microbes during ascending infection. However, little is known about how decidual stromal cells (DSCs) respond to microbial threat. Defining the contributions of individual cell types to the complex medley of inflammatory signals during chorioamnionitis could lead to improved interventions aimed at halting this disease. We review available published data supporting the role for DSCs in responding to microbial infection, with a special focus on their expression of pattern recognition receptors and evidence of their responsiveness to pathogen sensing. While DSCs likely play an important role in sensing and responding to infection during the pathogenesis of chorioamnionitis, important knowledge gaps and areas for future research are highlighted.
影响因子：
5.6
作者：
Yu XW;Zhang XW;Li X
通讯作者：
Li X