Pharmacogenomics: a systems approach.
Pharmacogenomics: a systems approach.
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DOI：
10.1002/wsbm.42
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发表时间：
2010-01
影响因子：
7.9
通讯作者：
Wang, Liewei
中科院分区：
文献类型：
--
作者：
Wang, Liewei
药物遗传学和药物基因组学涉及研究遗传在药物反应个体差异中的作用，这种表型从潜在的危及生命的药物不良反应到同样严重的疗效缺乏不等。药物基因学-药物基因组学是"个体化用药"运动的一个主要组成部分。药物遗传学研究最初集中在单基因性状，通常涉及药物代谢的遗传变异。然而，当代研究越来越多地涉及整个"途径"，包括药代动力学（PK）-影响药物达到其靶点的浓度的因素-和药效学（PD）-与药物靶点相关的因素，以及全基因组方法。药物遗传学的进展与人类基因组学的快速发展相结合，导致药物遗传学演变为药物基因组学。与此同时，药物反应的研究正在扩展到基因组学之外，包括药物转录组学和药物代谢组学，成为一个基于系统的学科。这一学科也越来越多地跨越"转化界面"进入临床，并被纳入药物开发过程和政府对这一过程的监管。本文将提供一个概述的药物遗传学药物基因组学的发展，科学的进步，这有助于这门学科的不断发展，转录组学和代谢组学数据纳入试图了解和预测药物反应表型的变化，以及与“翻译”的生物医学科学的这一重要方面到临床的挑战。
Pharmacogenetics and pharmacogenomics involve the study of the role of inheritance in individual variation in drug response, a phenotype that varies from potentially life-threatening adverse drug reactions to equally serious lack of therapeutic efficacy. Pharmacogenetics-pharmacogenomics represents a major component of the movement to `individualized medicine'. Pharmacogenetic studies originally focused on monogenic traits, often involving genetic variation in drug metabolism. However, contemporary studies increasingly involve entire `pathways' that include both pharmacokinetics (PKs)—factors that influence the concentration of a drug reaching its target(s)—and pharmacodynamics (PDs), factors associated with the drug target(s), as well as genome-wide approaches. The convergence of advances in pharmacogenetics with rapid developments in human genomics has resulted in the evolution of pharmacogenetics into pharmacogenomics. At the same time, studies of drug response are expanding beyond genomics to encompass pharmacotranscriptomics and pharmacometabolomics to become a systems-based discipline. This discipline is also increasingly moving across the `translational interface' into the clinic and is being incorporated into the drug development process and governmental regulation of that process. The article will provide an overview of the development of pharmacogenetics-pharmacogenomics, the scientific advances that have contributed to the continuing evolution of this discipline, the incorporation of transcriptomic and metabolomic data into attempts to understand and predict variation in drug response phenotypes as well as challenges associated with the `translation' of this important aspect of biomedical science into the clinic.
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影响因子：
5.4
作者：
Feng, WH;Hong, G;Kenney, SC
通讯作者：
Kenney, SC
影响因子：
--
作者：
EVANS, DAP;MANLEY, KA;MCKUSICK, VA
通讯作者：
MCKUSICK, VA
DOI：
10.1073/pnas.95.14.8170
发表时间：
1998-07-07
影响因子：
11.1
作者：
Beutler, E;Gelbart, T;Demina, A
通讯作者：
Demina, A
影响因子：
6.7
作者：
Dalén, P;Dahl, ML;Bertilsson, L
通讯作者：
Bertilsson, L
影响因子：
158.5
作者：
BOSMA, PJ;CHOWDHURY, JR;CHOWDHURY, NR
通讯作者：
CHOWDHURY, NR