The Role of MicroRNA in Cardiac Excitability
The Role of MicroRNA in Cardiac Excitability
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DOI：
10.1097/fjc.0b013e3181edb22c
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发表时间：
2010-11
影响因子：
3
通讯作者：
Zhiguo Wang
中科院分区：
文献类型：
--
作者：
Zhiguo Wang
心肌细胞是可兴奋的细胞，可以产生和传播兴奋;兴奋性是这些细胞的基本特征，其通过动作电位、跨膜电位随时间的变化以及离子通道、转运蛋白和细胞蛋白来反映。在肌肉中诱发的电兴奋必须通过所谓的兴奋-收缩耦合机制转化为机械收缩，并且心肌的适当收缩然后驱动血液泵送到身体循环。心律失常是一种电干扰，可导致心脏不规则跳动，从而导致血液泵送不足。心律失常通常是致命的，构成心脏性死亡的主要原因，特别是在心肌梗死和心力衰竭中的心脏性猝死。最近的研究已经导致发现microRNA（miRNAs）作为心脏兴奋性的新参与者，通过微调离子通道、转运蛋白和细胞蛋白的表达，其在许多条件下决定促心律失常性。这篇综述文章将对文献中的数据进行全面总结。首先介绍心脏兴奋性的基础知识，然后简要介绍miRNA的基础知识。然后，将描述和分析miRNA调节心脏兴奋性的研究。最后，将提出结论意见。
Cardiomyocytes are excitable cells that can generate and propagate excitations; excitability is a fundamental characteristic of these cells, which is reflected by action potential; the changes of transmembrane potential as a function of time; and orchestrated by ion channels, transporters, and cellular proteins. The electrical excitation evoked in muscles must be transformed into mechanical contraction through the so-called excitation-contraction coupling mechanism, and the proper contraction of cardiac muscles then drives pumping of blood to the body circulation. Arrhythmias are electrical disturbances that can result in irregular heart beating with consequent insufficient pumping of blood. Arrhythmias are often lethal, constituting a major cause for cardiac death, particularly sudden cardiac death, in myocardial infarction and heart failure. Recent studies have led to discovery of microRNAs (miRNAs) as a new player in the cardiac excitability by fine-tuning expression of ion channels, transporters, and cellular proteins, which determines the arrhythmogenicity in many conditions. This review article will give a comprehensive summary on the data available in the literature. The basics of cardiac excitability will first be introduced, followed by a brief introduction to the basics of miRNAs. Then, studies on regulation of cardiac excitability by miRNAs will be described and analyzed. Finally, concluding remarks will be provided.