Bone Microstructure at the Distal Tibia Provides a Strength Advantage to Males in Late Puberty: An HR-pQCT Study
Bone Microstructure at the Distal Tibia Provides a Strength Advantage to Males in Late Puberty: An HR-pQCT Study
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DOI：
10.1359/jbmr.091034
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发表时间：
2010-06-01
影响因子：
6.2
通讯作者：
McKay, Heather
中科院分区：
文献类型：
--
作者：
Burrows, Melonie;Liu, Danmei;McKay, Heather
骨骼是一个复杂的结构，具有多个层次的组织。先进的成像工具，如高分辨率(HR)外周定量计算机断层扫描(PQCT)，提供了研究骨微结构成分在性别和发育阶段之间的差异的机会。这项研究的目的是量化青春期男性和女性在年龄和性别方面的骨显微结构和骨强度的差异。我们使用HR-pQCT(XtremeCT，Sanco Medical，日内瓦，瑞士)评估总骨面积(ToA)、总骨密度(Tod)、骨小梁密度(TRD)、皮质骨密度(Cod)、皮质厚度(Cort.Th)、骨小梁体积(Bv/Tv)、骨小梁数量(Tb.N)、骨小梁厚度(Tb.Th)、骨小梁间距(Tb.Sp)、骨小梁间距标准差(Tb.Sp SD)和骨强度指数(BSI，女性133例，男性146例，年龄15~20岁。我们使用一般线性模型来确定年龄、性别组和年龄x性别交互作用的差异(p<；0.05)。在所有年龄段中，15岁和16岁的TOD、CoD、Cort.Th和BSI显著低于男性和女性的17至18岁和19至20岁。不同年龄的男女在TOA、TRD和BV/TV上没有差异。在性别之间，男性的ToA、TRD、Cort.Th、Bv/Tv、Tb.N和BSI显著大于女性；在各个年龄段，女性的Cod和Tb.Sp SD显著大于女性。与女性相比，男性更大、更致密的骨骼在很小的时候就赋予了骨骼强度优势。这些结构上的差异可能代表了女性骨骼承受压缩负荷的能力较差。C)2010年美国骨与矿物研究学会。
Bone is a complex structure with many levels of organization. Advanced imaging tools such as high-resolution (HR) peripheral quantitative computed tomography (pQCT) provide the opportunity to investigate how components of bone microstructure differ between the sexes and across developmental periods. The aim of this study was to quantify the age- and sex-related differences in bone microstructure and bone strength in adolescent males and females. We used HR-pQCT (XtremeCT, Scanco Medical, Geneva, Switzerland) to assess total bone area (ToA), total bone density (ToD), trabecular bone density (TrD), cortical bone density (CoD), cortical thickness (Cort.Th), trabecular bone volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular spacing standard deviation (Tb.Sp SD), and bone strength index (BSI, mg(2)/mm(4)) at the distal tibia in 133 females and 146 males (15 to 20 years of age). We used a general linear model to determine differences by age- and sex-group and age x sex interactions (p < 0.05). Across age categories, ToD, CoD, Cort.Th, and BSI were significantly lower at 15 and 16 years compared with 17 to 18 and 19 to 20 years in males and females. There were no differences in ToA, TrD, and BV/TV across age for either sex. Between sexes, males had significantly greater ToA, TrD, Cort.Th, BV/TV, Tb.N, and BSI compared with females; CoD and Tb.Sp SD were significantly greater for females in every age category. Males' larger and denser bones confer a bone-strength advantage from a young age compared with females. These structural differences could represent bones that are less able to withstand loads in compression in females. C) 2010 American Society for Bone and Mineral Research.