Difference in imaging biomarkers of neurodegeneration between early and late-onset amnestic Alzheimer's disease
Difference in imaging biomarkers of neurodegeneration between early and late-onset amnestic Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2017.02.010
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发表时间：
2017-06-01
影响因子：
4.2
通讯作者：
Ceccaldi, Mathieu
中科院分区：
文献类型：
--
作者：
Aziz, Anne-Laure;Giusiano, Bernard;Ceccaldi, Mathieu
早发性阿尔茨海默病(EoAD)和迟发性阿尔茨海默病(LOAD)患者的神经影像生物标志物不同。这些变化是否反映了认知的异质性或疾病严重性的差异仍不得而知。本研究旨在研究脑脊液淀粉样蛋白生物标志物阳性的轻度遗忘型阿尔茨海默病患者的神经影像生物标志物根据发病年龄的变化。两组患者在评估语言和视觉识别记忆的任务中都受到了损害。Eoad患者表现出更严重的执行和语言缺陷，而Load患者表现出更严重的语义记忆障碍。在负重和负重时，低代谢受累于双侧顶叶交界处和后扣带回皮质。在EOAD中，萎缩是广泛的，包括额颞顶区，而它仅限于负载中的颞区。Eoad组萎缩体积大于Load组。两组的亚代谢体积相似。尽管Eoad的低代谢程度相似，但Eoad的萎缩程度更大，可能反映了不同的潜在病理生理过程，不同的基于葡萄糖的代偿机制，或不同程度的病前萎缩损害。(C)2017 Elsevier Inc.保留所有权利。
Neuroimaging biomarkers differ between patients with early-onset Alzheimer's disease (EOAD) and lateonset Alzheimer's disease (LOAD). Whether these changes reflect cognitive heterogeneity or differences in disease severity is still unknown. This study aimed at investigating changes in neuroimaging biomarkers, according to the age of onset of the disease, in mild amnestic Alzheimer's disease patients with positive amyloid biomarkers in cerebrospinal fluid. Both patient groups were impaired on tasks assessing verbal and visual recognition memory. EOAD patients showed greater executive and linguistic deficits, while LOAD patients showed greater semantic memory impairment. In EOAD and LOAD, hypometabolism involved the bilateral temporoparietal junction and the posterior cingulate cortex. In EOAD, atrophy was widespread, including frontotemporoparietal areas, whereas it was limited to temporal regions in LOAD. Atrophic volumes were greater in EOAD than in LOAD. Hypometabolic volumes were similar in the 2 groups. Greater extent of atrophy in EOAD, despite similar extent of hypometabolism, could reflect different underlying pathophysiological processes, different glucose-based compensatory mechanisms or distinct level of premorbid atrophic lesions. (C) 2017 Elsevier Inc. All rights reserved.