Microinjection of a conserved peptide sequence of p34cdc2 induces a Ca2+ transient in oocytes.
Microinjection of a conserved peptide sequence of p34cdc2 induces a Ca2+ transient in oocytes.
复制标题
显微注射 p34cdc2 的保守肽序列会在卵母细胞中诱导 Ca2 瞬变。
DOI：
10.1126/science.2153316
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发表时间：
1990
期刊：
影响因子：
56.9
通讯作者：
M. Dorée
中科院分区：
文献类型：
--
作者：
A. Picard;J. Cavadore;P. Lory;J. Bernengo;C. Ojeda;M. Dorée
The product of the yeast cell cycle control gene cdc2, and its homologs in higher eukaryotes (p34cdc2), all contain a perfectly conserved sequence of 16 amino acids that has not been found in any other protein sequence. Microinjection of this peptide triggers a specific increase in the concentration of intracellular free Ca2+ that originates from intracellular stores in both starfish and Xenopus oocytes. Thus, p34cdc2 might interact through its conserved peptide domain with some component of the Ca2(+)-regulatory system.
