Positron emission tomography compartmental models
Positron emission tomography compartmental models
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DOI：
10.1097/00004647-200106000-00002
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发表时间：
2001-06-01
影响因子：
6.3
通讯作者：
Cunningham, VJ
中科院分区：
文献类型：
--
作者：
Gunn, RN;Gunn, SR;Cunningham, VJ
本文介绍了正电子发射断层扫描 (PET) 中使用的隔室模型的理论。血浆输入模型和参考组织输入模型都被考虑。推导了一般理论，并根据系统的脉冲响应函数来表征系统。理论表明，系统的宏观参数可以简单地由脉冲响应函数的系数确定。这些结果在放射性配体结合研究的背景下进行讨论。结果表明，结合电位与目前 PET 中使用的所有血浆和参考组织输入模型的脉冲响应函数的积分相关。本文还介绍了示踪剂在血液中行为的一般区室描述，从而可以评估参考组织输入模型中血容量引起的偏差。
The current article presents theory for compartmental models used in positron emission tomography (PET). Both plasma input models and reference tissue input models are considered. General theory is derived and the systems are characterized in terms of their impulse response functions. The theory shows that the macro parameters of the system may be determined simply from the coefficients of the impulse response functions. These results are discussed in the context of radioligand binding studies. It is shown that binding potential is simply related to the integral of the impulse response functions for all plasma and reference tissue input models currently used in PET. This article also introduces a general compartmental description for the behavior of the tracer in blood, which then allows for the blood volume-induced bias in reference tissue input models to be assessed.