Saringosterol from Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient Mice.
Saringosterol from Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient Mice.
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来自sargassum fusiforme的肉烟素调节胆固醇代谢，并减轻APOE缺陷小鼠的动脉粥样硬化。
DOI：
10.3390/md19090485
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发表时间：
2021-08-26
期刊：
影响因子：
5.4
通讯作者：
Liu H
中科院分区：
文献类型：
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作者：
Yan Y;Niu Z;Wang B;Zhao S;Sun C;Wu Y;Li Y;Ying H;Liu H
Dysregulation of cholesterol homeostasis is a major risk factor of atherosclerosis, which can lead to serious health problems, including heart attack and stroke. Liver X receptor (LXR) α and β are transcription factors belonging to the nuclear receptor superfamily, which play important roles in cholesterol homeostasis. Selectively activating LXRβ provides a promising strategy for the treatment of atherosclerosis. Here, we employed atherosclerotic apoE-knockout mice to evaluate the effects of saringosterol, a phytosterol with potent and selective action for LXRβ, which we identified previously in edible marine seaweed Sargassum fusiforme. We found that saringosterol treatment reduced the atherosclerotic plaque burden without having undesirable adverse hepatic effects in apoE-deficient mice fed an atherogenic diet. Meanwhile, reduced serum levels of cholesterol, accompanied by altered expression of LXR-regulated genes involved in cholesterol absorption, transport, efflux, excretion, and elimination, were observed in apoE-knockout mice after saringosterol treatment. Together, our study not only establishes saringosterol as an effective cholesterol-lowering and anti-atherogenic phytosterol but also provides insights into the underlying mechanism.
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影响因子：
5.3
作者：
Lee SD;Tontonoz P
通讯作者：
Tontonoz P
影响因子：
6.1
作者：
Chen, Zhen;Liu, Jiao;Liu, Hongbing
通讯作者：
Liu, Hongbing
影响因子：
2.7
作者：
Matsuda, Takayuki;Okuda, Ayumu;Shibuya, Kimiyuki
通讯作者：
Shibuya, Kimiyuki
DOI：
10.1073/pnas.182199799
发表时间：
2002-09-03
影响因子：
11.1
作者：
Tangirala, RK;Bischoff, ED;Schulman, IG
通讯作者：
Schulman, IG
DOI：
10.1016/j.bbadis.2021.166121
发表时间：
2021-06-01
期刊：
Biochimica et biophysica acta. Molecular basis of disease
影响因子：
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作者：
通讯作者：
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