Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
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DOI：
10.1152/ajpendo.90710.2008
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发表时间：
2009-04-01
影响因子：
5.1
通讯作者：
Kim, Jae Bum
中科院分区：
文献类型：
--
作者：
Kim, Woo Sik;Lee, Yun Sok;Kim, Jae Bum
金志贤、李永生、车世贤、郑、崔顺实、李美禄、吴GT、朴H-S、李国柱、连恩医学、金俊斌。黄连素通过控制中枢和外周AMPK活性改善肥胖患者的脂质失调。AM J生理学内分泌代谢酶296：E812-E819,2009。首次发表于2009年1月27日；DOI：10.1152/ajpendo.90710.2008。-AMP激活的蛋白激酶(AMPK)在调节全身能量平衡方面发挥着重要作用。近年来的研究表明，黄连素(berberine，BBR)通过激活外周组织中的AMPK，在肥胖和糖尿病大鼠模型中发挥抗肥胖和抗糖尿病的作用。在这里，我们表明，BBR通过中枢和外周作用改善肥胖小鼠的血脂失调和脂肪肝。在肥胖的db/db和ob/ob小鼠中，BBR治疗降低了肝脏重量、肝脏和血浆甘油三酯以及胆固醇含量。在db/db小鼠的肝脏和肌肉中，BBR促进AMPK活性和脂肪酸氧化，并改变与脂质代谢有关的基因的表达。此外，侧脑室注射BBR可降低骨骼肌中丙二酰辅酶A的水平，刺激脂肪酸氧化基因的表达。总之，这些数据表明，BBR可以改善肥胖受试者的脂肪肝，这可能不仅通过外周AMPK激活，而且还通过中枢神经系统的神经信号来调节。
Kim WS, Lee YS, Cha SH, Jeong HW, Choe SS, Lee M-R, Oh GT, Park H-S, Lee K-U, Lane MD, Kim JB. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. Am J Physiol Endocrinol Metab 296: E812-E819, 2009. First published January 27, 2009; doi:10.1152/ajpendo.90710.2008.-AMP-activated protein kinase (AMPK) plays an important role in regulating whole body energy homeostasis. Recently, it has been demonstrated that berberine (BBR) exerts antiobesity and antidiabetic effects in obese and diabetic rodent models through the activation of AMPK in peripheral tissues. Here we show that BBR improves lipid dysregulation and fatty liver in obese mice through central and peripheral actions. In obese db/db and ob/ob mice, BBR treatment reduced liver weight, hepatic and plasma triglyceride, and cholesterol contents. In the liver and muscle of db/db mice, BBR promoted AMPK activity and fatty acid oxidation and changed expression of genes involved in lipid metabolism. Additionally, intracerebroventricular administration of BBR decreased the level of malonyl-CoA and stimulated the expression of fatty acid oxidation genes in skeletal muscle. Together, these data suggest that BBR would improve fatty liver in obese subjects, which is probably mediated not only by peripheral AMPK activation but also by neural signaling from the central nervous system.