Extensive learning is associated with gray matter changes in the right hippocampus
Extensive learning is associated with gray matter changes in the right hippocampus
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DOI：
10.1016/j.neuroimage.2015.10.056
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发表时间：
2016-01-15
期刊：
影响因子：
5.7
通讯作者：
Zimmer, Claus
中科院分区：
文献类型：
--
作者：
Koch, Kathrin;Reess, Tim Jonas;Zimmer, Claus
基于纵向体素的形态计量学研究表明，在广泛的认知学习后，海马区灰质体积增加。此外，越来越多的证据表明，下丘脑与学习和记忆有关。本研究采用纵向自由潜水分析和海马子场分割的方法，研究了14周的强化学习对医学生样本的海马灰质体积的影响，并与没有从事任何认知学习活动的对照组进行了比较。我们发现，广泛的学习导致右侧海马体体积显著增加。左侧海马体和下丘脑的体积没有变化。目前的发现强调了海马体在语义学习和记忆过程中的作用，并为海马体在认知学习背景下的神经再生能力提供了进一步的证据。(C)2015 Elsevier Inc.保留所有权利。
Longitudinal voxel-based morphometry studies have demonstrated increases in gray matter volume in hippocampal areas following extensive cognitive learning. Moreover, there is increasing evidence for the relevance of the subiculum in the context of learning and memory. Using longitudinal FreeSurfer analyses and hippocampus subfield segmentation the present study investigated the effects of 14 weeks of intensive learning on hippocampal and subicular gray matter volume in a sample of medical students compared to control subjects not engaged in any cognitive learning activities. We found that extensive learning resulted in a significant increase of right hippocampal volume. Volume of the left hippocampus and the subiculum remained unchanged. The current findings emphasize the role of the hippocampus in semantic learning and memory processes and provide further evidence for the neuroplastic ability of the hippocampus in the context of cognitive learning. (C) 2015 Elsevier Inc. All rights reserved.