Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction.
Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction.
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DOI：
10.1126/stke.2003.187.re9
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发表时间：
2003-06-17
期刊：
影响因子：
--
通讯作者：
Hsueh, Aaron J W
中科院分区：
文献类型：
--
作者：
Ben-Shlomo, Izhar;Yu Hsu, Sheau;Hsueh, Aaron J W
多细胞生物体中的细胞间通讯需要通过细胞表面蛋白将细胞外信号传递到细胞内部。人类和几种模式生物的基因组序列的可用性促进了几种人类质膜受体家族的鉴定，并允许分析其同源性。这篇综述提供了一个全球性的分类最已知的信号转导相关的受体酶，招聘，和潜在的转录因子。在当前文献中追踪了已知的人质膜信号受体家族的进化，并通过序列相关性进行了验证。这种全球性的分析揭示了受体进化过程中反复出现的主题，并允许制定受体起源的假设。参与信号传导的人受体家族（通道除外）见人质膜受体组数据库。
Intercellular communication in multicellular organisms requires the relay of extracellular signals by cell surface proteins to the interiors of cells. The availability of genome sequences from humans and several model organisms has facilitated the identification of several human plasma membrane receptor families and allowed the analysis of their phylogeny. This review provides a global categorization of most known signal transduction-associated receptors as enzymes, recruiters, and latent transcription factors. The evolution of known families of human plasma membrane signaling receptors was traced in current literature and validated by sequence relatedness. This global analysis reveals themes that recur during receptor evolution and allows the formulation of hypotheses for the origins of receptors. The human receptor families involved in signaling (with the exception of channels) are presented in the Human Plasma Membrane Receptome database.