Quantification of Liver Surface Nodularity at CT: Utility for Detection of Portal Hypertension
Quantification of Liver Surface Nodularity at CT: Utility for Detection of Portal Hypertension
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DOI：
10.1148/radiol.2018181131
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发表时间：
2018-12-01
期刊：
影响因子：
19.7
通讯作者：
Ronot, Maxime
中科院分区：
文献类型：
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作者：
Sartoris, Riccardo;Rautou, Pierre-Emmanuel;Ronot, Maxime
目的：为了确定肝表面结节化（LSN）的定量是否提供了肝硬化患者中存在临床显著门脉高压（CSPH）的估计。材料和方法：这项回顾性研究包括一个培训队列（n = 189）和一个单独的外部验证队列（n = 78），均由2010年至2016年期间接受腹部CT和肝静脉压力梯度（HVPG）测量的肝硬化患者组成。从CT图像和血清实验室中获得LSN评分、肝脏和脾脏体积、肝脏与脾脏体积比、血小板计数与脾脏直径比、Iranmanesh评分、天冬氨酸氨基转移酶与血小板比率指数和纤维化-4指数。用受试者工作特征曲线下面积（AUROC）评价各种试验预测CSPH的准确性，并使用DeLong检验进行比较。结果：189例患者进行了分析（119名男性[平均年龄6岁标准差，57岁6 11;范围，29-81岁]和70名女性[平均年龄，61岁6 10;范围，34-83岁];总的平均年龄，58岁6 10;范围，29-83岁）。共有102例患者（54%）患有CSPH。LSN评分与HVPG相关（r = 0.75; P，
Purpose: To determine whether quantification of liver surface nodularity (LSN) provides an estimate of the presence of clinically significant portal hypertension (CSPH) in patients with cirrhosis.Materials and Methods: This retrospective study included a training cohort (n = 189) and separate external validation cohort (n = 78), both composed of patients with cirrhosis who underwent abdominal CT and hepatic venous pressure gradient (HVPG) measurement between 2010 and 2016. The LSN score, liver and spleen volumes, liver-to-spleen volume ratio, platelet count to spleen diameter ratio, Iranmanesh score, aspartate amino transferase-to-platelet ratio index, and Fibrosis-4 index were derived from CT images and serum laboratories. The accuracy of the various tests for predicting CSPH was evaluated with area under the receiver operating characteristic curve (AUROC) and compared by using the DeLong test. Student t test and Pearson correlation coefficient were used.Results: One hundred eighty-nine patients were analyzed (119 men [mean age 6 standard deviation, 57 years 6 11; range, 29-81 years] and 70 women [mean age, 61 years 6 10; range, 34-83 years]; overall mean age, 58 years 6 10; range, 29-83 years). A total of 102 patients (54%) had CSPH. LSN score correlated with HVPG (r = 0.75; P,