Comparison of the Cozart DDS 801 on-site drug test device and gas chromatography/mass spectrometry (GC/MS) confirmation results of cannabis and cocaine in oral fluid specimens
Comparison of the Cozart DDS 801 on-site drug test device and gas chromatography/mass spectrometry (GC/MS) confirmation results of cannabis and cocaine in oral fluid specimens
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口腔液标本中大麻和可卡因的 Cozart DDS 801 现场药物测试装置与气相色谱/质谱 (GC/MS) 确认结果的比较
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发表时间：
2014
期刊：
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通讯作者：
A. Mora
中科院分区：
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作者：
A. Arroyo;Marta Sánchez;E. Barbería;María Barbal;M. Marrón;A. Mora
毒品影响下驾驶（DUID）是世界各地的一个问题。本研究的目的是通过将现场结果与验证性气相色谱/质谱（GC/MS）口腔液分析结果进行比较，评估口腔液筛查设备CozartDDS 801的可靠性。该研究在加泰罗尼亚（西班牙）进行，样本为2180份口腔液样本，样本取自涉嫌在药物滥用影响下驾驶的受试者，并由警察在2009-2010年期间收集。确定了大麻和可卡因检验的统计参数。可卡因的敏感性、特异性、阳性预测值、阴性预测值、阳性似然比和阴性似然比分别为92%、90%、95%、85%、9.44和0.09。大麻的敏感性、特异性、阳性预测值、阴性预测值、阳性似然比和阴性似然比分别为87%、86%、94%、73%、6.15和0.6。可卡因的准确率为91%，大麻为86%。CozartDDS 801药物检测系统是一种简单易用的口腔液中可卡因和大麻的筛查工具，在制造商建立的初始筛查截止值下，通过GC/MS分析确认。该系统已证明其性能可接受。
Driving under the influence of drugs (DUID) is a problem around the world. The objective of this study is to assess the reliability of the oral fluid screening device the Cozart DDS 801 by comparing the on-site results with confirmatory gas chromatography/mass spectrometry (GC/MS) oral fluid analysis. The study was carried out in Catalonia (Spain) with a sample of 2180 oral fluid specimens taken from subjects suspected of driving under the influence of drugs of abuse, and collected by police officers during 2009–2010. Statistical parameters of the tests were determined for cannabis and cocaine. The sensitivity, specificity, predictive positive value, predictive negative value, likelihood positive ratio and likelihood negative ratio for cocaine were 92%, 90%, 95%, 85%, 9.44, and 0.09 respectively. Sensitivity, specificity, predictive positive value, predictive negative value, likelihood positive ratio and likelihood negative ratio for cannabis were 87%, 86%, 94%, 73%, 6.15 and 0.6 respectively. Accuracy was 91% for cocaine and 86% for cannabis. The Cozart DDS 801 drug test system is a simple to use screening tool for cocaine and cannabis in oral fluid, at initial screening cut-off established by the manufacturer, confirmed with a GC/MS analysis. The system has demonstrated its acceptable performance.