Ethnic differences in cardiovascular risk factor burden among middle-aged women: Study of Women's Health Across the Nation (SWAN)
Ethnic differences in cardiovascular risk factor burden among middle-aged women: Study of Women's Health Across the Nation (SWAN)
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DOI：
10.1016/j.ahj.2004.08.027
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发表时间：
2005-06-01
影响因子：
4.8
通讯作者：
Pasternak, RC
中科院分区：
文献类型：
--
作者：
Matthews, KA;Sowers, MF;Pasternak, RC
研究背景：我们评估了10年心肌梗死或冠状动脉死亡风险的种族差异，这些风险来自于Fragrance风险方程，以及女性新出现的心血管疾病风险因素的复合测量，以及教育程度、地理位置和生活方式的统计调整是否减弱了风险的种族差异。心脏病或糖尿病，年龄在42至52岁之间（1400名白人，729名非洲裔美国人，226名西班牙裔，231名中国人和248名日本人）测量血压、血脂和脂蛋白、腰围、血糖、胰岛素、脂蛋白（a）、纤维蛋白原、因子VII、纤溶酶原激活物抑制剂、组织型纤溶酶原激活物抗原、和高敏C反应蛋白Frachial风险评分和风险因素的分布中的前四分位数的Frachial评分（称为复合负担）的危险因素的数量进行了calculated.Results的两个汇总得分的未调整的平均值高于非洲裔美国人和西班牙裔比其他群体。教育和地理位置的统计调整占种族差异的大部分，生活方式对综合负担评分的影响很小。最大的种族差异是明显的腰围，脂蛋白（a），高敏C-反应蛋白，和未经治疗的血压。结论一个相当大的一部分与种族相关的风险可以归因于社会经济地位和地理位置。随着美国人口的种族构成变得更加多样化，重要的是要了解一些少数群体中存在的心血管疾病风险因素负担。
Background We evaluated ethnic differences in the 10-year risk of myocardial infarction or coronary death derived from Framingham risk equation and in a composite measure of emerging cardiovascular disease risk factors in women and whether statistical adjustments for educational attainment, geographic location, and lifestyle attenuated the magnitude of the ethnic differences in risk.Methods Two thousand eight hundred thirty-four premenopausal women free of stroke, heart disease, or diabetes and aged of 42 to 52 years (1400 whites, 729 African American, 226 Hispanic, 231 Chinese, and 248 Japanese) had measurements of blood pressure, lipids and lipoproteins, waist circumference, glucose, insulin, lipoprotein(a), fibrinogen, factor VII, plasminogen activator inhibitor, tissue-type plasminogen activator antigen, and high-sensitivity C-reactive protein. Framingham risk score and number of risk factors in the top quartile of the distribution of risk factors not included in the Framingham score (called composite burden) were calculated.Results The unadjusted mean values for the two summary scores were higher among African Americans and Hispanics than other groups. Statistical adjustments for education and geographical site accounted for a majority of the ethnic differences, with an additional small effect of lifestyle for the composite burden score. Largest ethnic differences were apparent for waist circumference, lipoprotein(a), high-sensitivity C-reactive protein, and untreated blood pressure.Conclusions A substantial part of the risk associated with ethnicity can be attributed to socioeconomic status and geographical location. As the ethnic composition of the United States population becomes more diverse, it is important to appreciate the cardiovascular disease risk factor burden present in some minority groups.