Genetic Admixture, Self-Reported Ethnicity, Self-Estimated Admixture, and Skin Pigmentation Among Hispanics and Native Americans
Genetic Admixture, Self-Reported Ethnicity, Self-Estimated Admixture, and Skin Pigmentation Among Hispanics and Native Americans
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DOI：
10.1002/ajpa.20945
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发表时间：
2009-04-01
影响因子：
2.8
通讯作者：
Shriver, Mark D.
中科院分区：
文献类型：
--
作者：
Klimentidis, Yann C.;Miller, Geoffrey F.;Shriver, Mark D.
种族和生物学之间的关系是人类学家，生物医学科学家和历史学家感兴趣的理解人类群体是如何构建的。种族自我认同在最近的混合群体，如西班牙裔，非洲裔美国人和美洲原住民（NA）可能是复杂的，由于这些群体内的个体混合比例和社会环境的异质性。本研究探讨自我认定的种族，自我估计的混合比例，皮肤色素沉着，和遗传标记估计的混合比例之间的关系。这些措施进行了评估，使用问卷调查，肤色测量，基因分型的76个祖先的信息标记物，在170个西班牙裔和NAs从新墨西哥州，一个国家的NA和欧洲（EU）血统的人之间的相互作用的复杂历史而闻名。结果表明，NAs低估了他们的程度欧盟混合，西班牙裔低估了他们的程度NA混合。在西班牙裔，遗传标记估计的混合物是更好地预测前额皮肤色素沉着比自我估计的混合物。We.还发现，自认为是“一半白人，一半西班牙裔”和“西班牙人”的西班牙裔个体比自认为是“墨西哥人”和“墨西哥裔美国人”的个体具有更低水平的NA混合物。“这些结果突出了文化和生物学在个人如何识别和看待自己方面的相互作用，并对如何在医疗环境中评估种族和疾病风险产生了影响。Am J Phys Antbropol 138：375- 383，2009，（c）2008Wiley-Ligs，Inc.
The relationship between ethnicity and biology is of interest to anthropologists, biomedical scientists, and historians in understanding how human groups are constructed. Ethnic self-identification in recently admixed groups such as Hispanics, African Americans, and Native Americans (NA) is likely to be complex due to the heterogeneity in individual admixture proportions and social environments within these groups. This study examines the relationships between self-identified ethnicity, self-estimated admixture proportions, skin pigmentation, and genetic marker estimated admixture proportions. These measures were assessed using questionnaires, skin color measurements, and genotyping of a panel of 76 ancestry informative markers, among 170 Hispanics and NAs from New Mexico, a state known for its complex history of interactions between people of NA and European (EU) ancestry. Results reveal that NAs underestimate their degree of EU admixture, and that Hispanics underestimate their degree of NA admixture. Within Hispanics, genetic-marker estimated admixture is better predicted by forehead skin pigmentation than by self-estimated admixture. We. also find that Hispanic individuals self-identified as "half-White, half Hispanic" and "Spanish" have lower levels of NA admixture than those self-identified as "Mexican" and "Mexican American." Such results highlight the interplay between culture and biology in how individuals identify and view themselves, and have implications for how ethnicity and disease risk are assessed in a medical setting. Am J Phys Antbropol 138:375-383,2009, (c) 2008Wiley-Ligs, Inc.