Long-term, high-dose benzodiazepine prescriptions in veteran patients with PTSD: Influence of preexisting alcoholism and drug-abuse diagnoses
Long-term, high-dose benzodiazepine prescriptions in veteran patients with PTSD: Influence of preexisting alcoholism and drug-abuse diagnoses
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DOI：
10.1002/jts.20254
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发表时间：
2007-10-01
影响因子：
3.3
通讯作者：
Fiore, Louis D.
中科院分区：
文献类型：
--
作者：
Hermos, John A.;Young, Melissa M.;Fiore, Louis D.
对新英格兰退伍军人综合服务网络的数据库进行了分析，以确定向创伤后应激障碍(PTSD)患者分发长期、大剂量抗焦虑药物苯二氮卓类药物处方的相关因素，以及现有的酒精中毒和/或药物滥用诊断。在2183名PTSD患者中，234人接受了阿普唑仑、氯硝西潘、安定或劳拉西潘的平均10%的最高日剂量，高于通常的推荐量。最高剂量的处方更常开给有药物滥用诊断的患者。在有创伤后应激障碍和酒精中毒的患者中，年龄较小、滥用药物、同时服用另一种苯二氮卓类药物和羟考酮/对乙酰氨基酚的患者独立预测高剂量。结果表明，对于患有创伤后应激障碍的退伍军人患者来说，酒精中毒本身与大剂量苯二氮卓类药物无关，但现有的药物滥用诊断确实增加了这种风险。
Databases from the New England Veterans Integrated Service Network were analyzed to determine factors associated with long-term, high-dose anxiolytic benzodiazepine prescriptions dispensed to patients with posttraumatic stress disorder (PTSD) and existing alcoholism and/or drug abuse diagnoses. Among 2,183 PTSD patients, 234 received the highest 10% average daily doses for alprazolam, clonazepam, diazepam, or lorazepam, doses above those typically recommended. Highest doses were more commonly prescribed to patients with existing drug abuse diagnoses. Among patients with PTSD and alcoholism, younger age, drug abuse, and concurrent prescriptions for another benzodiazepine and oxycodone/acetaminophen independently predicted high doses. Results indicare that for veteran patients with PTSD, alcoholism alone is not associated with high-dose benzodiazepines, but existing drug abuse diagnoses do increase that risk.