Dual Protective and Cytotoxic Benefits of Mesenchymal Stem Cell Therapy in Combination with Chemotherapy/Radiotherapy for Cancer Patients
Dual Protective and Cytotoxic Benefits of Mesenchymal Stem Cell Therapy in Combination with Chemotherapy/Radiotherapy for Cancer Patients
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DOI：
10.1615/critreveukaryotgeneexpr.2015013843
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发表时间：
2015-01-01
影响因子：
1.6
通讯作者：
Javanmard, Shaghayegh Haghjooy
中科院分区：
文献类型：
--
作者：
Hendijani, Fatemeh;Javanmard, Shaghayegh Haghjooy
癌症是世界上一个主要的健康问题，科学家们寻求比现有治疗药物具有更高疗效和更低毒性的创新治疗策略。通过这种方式，干细胞研究人员试图揭示最终使患者受益的新途径。干细胞研究已证实间充质干细胞具有抗肿瘤活性，其富含蛋白质的分泌组也显示出类似的作用。MSC还分泌在愈合和再生过程中发挥积极作用的细胞因子。由于其已知的可塑性，MSC在不同的环境中显示出各种特性和功能，这取决于它们与各种细胞类型和组织的相互作用。因此，我们假设MSC疗法与抗癌药物联合可以增强对癌细胞的细胞毒性作用。此外，由于其再生能力，MSC可以保护正常组织免受不良细胞毒性药物反应。它们还可以帮助从这些毒性损伤或癌症治疗期间发生的全身病理事件中拯救受损组织。MSC疗法可以使对癌症和正常细胞的有益效果加倍。随着我们对系统生物学和生物技术方法学的了解不断进步，这种想法可以作为一种治疗选择。
Cancer is a major health problem in the world, and scientists seek innovative treatment strategies with higher efficacy and lower toxicity than the existing therapeutic agents. In this way, stem cell researchers try to reveal new pathways that will eventually benefit patients. Stem cell research has proven that mesenchymal stem cells (MSCs) possess anticancer activities, and their protein-rich secretome showed similar effects. MSCs also secrete cytokines that play an active role in healing and regeneration processes. Because of their known plasticity, MSCs display a variety of characteristics and functions in different environments, depending on their interactions with various cell types and tissues. Therefore, we hypothesize that MSC therapy in combination with anticancer medicines can potentiate cytotoxic effects on cancer cells. In addition, because of their regenerative capacity, MSCs can protect normal tissues from adverse cytotoxic drug reactions. They may also help rescue injured tissues from these toxic damages or systemic pathological events that occur during cancer treatment. MSC therapy may double the beneficial effects on cancer and normal cells. As our knowledge of systems biology and biotechnological methodology is progressing, this idea can move forward as a treatment option.