Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm
Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm
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DOI：
10.1093/brain/awg180
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发表时间：
2003-08-01
期刊：
影响因子：
14.5
通讯作者：
Farah, MJ
中科院分区：
文献类型：
--
作者：
Fellows, LK;Farah, MJ
额叶如何支持行为灵活性？一个关键要素是当刺激的强化值发生变化时调整反应的能力。在猴子中，这种能力（一种称为逆转学习的情感转变形式）取决于眶额皮层。本研究探讨了人类逆向学习的解剖学基础。在简单的逆转学习任务中，将腹内侧前额叶皮层损伤的受试者与背外侧额叶损伤的受试者以及正常对照进行比较。这两种形式的额叶损伤都不会影响最初的刺激强化学习。腹内侧额叶损伤选择性地损害逆转学习。
How do the frontal lobes support behavioural flexibility? One key element is the ability to adjust responses when the reinforcement value of stimuli change. In monkeys, this ability-a form of affective shifting known as reversal learning-depends on orbitofrontal cortex. The present study examines the anatomical bases of reversal learning in humans. Subjects with lesions of the ventromedial prefrontal cortex were compared with a group with dorsolateral frontal lobe damage, as well as with normal controls on a simple reversal learning task. Neither form of frontal damage affected initial stimulus-reinforcement learning; ventromedial frontal damage selectively impaired reversal learning.