A structural analysis of the myelin sheath in the central nervous system.
A structural analysis of the myelin sheath in the central nervous system.
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DOI：
10.1083/jcb.34.2.555
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发表时间：
1967-08
期刊：
影响因子：
--
通讯作者：
Dembitzer HM
中科院分区：
文献类型：
--
作者：
Hirano A;Dembitzer HM
用电子显微镜观察了不同实验条件下大鼠脑白质的变化。髓鞘除了通常的结构外，还发现了几种不同寻常的结构。这些变异包括：(a)内外环内形成的细胞器，(b)主要致密线未融合部分的孤立细胞质岛，(c)鞘和轴突之间明显不连接的细胞过程，以及(d)同心的双髓鞘。一个广义的模型的髓鞘基于一个假设的展开鞘描述。髓鞘由铲状髓鞘片组成，周围是连续增厚的细胞质边缘。大多数不寻常的髓鞘结构被解释为这个基本主题的简单变化。在这个模型的帮助下，对髓鞘的形成提供了一个解释。这种解释涉及到髓磷脂形成可以发生在髓磷脂本身附近的所有细胞质区域，并且相邻的髓磷脂薄片可以相互移动。
The cerebral white matter of rats subjected to a variety of noxious experimental conditions was examined in the electron microscope. Several unusual configurations of the myelin sheath are identified in addition to the usual configuration. These variations include the presence of (a) formed organelles within the inner and outer loops, (b) isolated islands of cytoplasm in unfused portions of the major dense lines, (c) apparently unconnected cell processes between the sheath and the axon, and (d) concentric, double myelin sheaths. A generalized model of the myelin sheath based on a hypothetical unrolling of the sheath is described. It consists of a shovel-shaped myelin sheet surrounded by a continuous thickened rim of cytoplasm. Most of the unusual myelin configurations are explained as simple variations on this basic theme. With the help of this model, an explanation of the formation of the myelin sheath is offered. This explanation involves the concept that myelin formation can occur at all cytoplasmic areas adjacent to the myelin proper and that adjacent myelin lamellae can move in relation to each other.