Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.
Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.
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DOI：
10.2174/1875933501103010038
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Dewhirst MW
中科院分区：
文献类型：
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作者：
Landon CD;Park JY;Needham D;Dewhirst MW
脂质体药物递送的总体目标是选择性地将药物递送靶向至患病组织，同时最小化药物递送至关键的正常组织。本文综述了温敏脂质体的研究进展，特别是低温敏感脂质体的研究进展。我们简要介绍了LTSL的材料设计，并强调了温度触发药物释放背后的可能机制。最新的临床前和临床研究的进展和结果，证明了增强的药物输送与热疗和脂质体的联合治疗提供了一个完整的审查，以及对癌症的临床前景，将受益于热疗作为温度触发的化疗药物的辅助治疗。这篇综述讨论了温度敏感脂质体在实验室中开发到目前在临床前和临床环境中使用的想法、目标和过程。
The overall objective of liposomal drug delivery is to selectively target drug delivery to diseased tissue, while minimizing drug delivery to critical normal tissues. The purpose of this review is to provide an overview of temperature-sensitive liposomes in general and the Low Temperature-Sensitive Liposome (LTSL) in particular. We give a brief description of the material design of LTSL and highlight the likely mechanism behind temperature-triggered drug release. A complete review of the progress and results of the latest preclinical and clinical studies that demonstrate enhanced drug delivery with the combined treatment of hyperthermia and liposomes is provided as well as a clinical perspective on cancers that would benefit from hyperthermia as an adjuvant treatment for temperature-triggered chemotherapeutics. This review discusses the ideas, goals, and processes behind temperature-sensitive liposome development in the laboratory to the current use in preclinical and clinical settings.