Continuous synthesis of monodisperse iron@iron oxide core@shell nanoparticles
Continuous synthesis of monodisperse iron@iron oxide core@shell nanoparticles
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DOI：
10.1016/j.cej.2020.125299
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发表时间：
2020-09
影响因子：
15.1
通讯作者：
Julien Mahin;L. Torrente‐Murciano
中科院分区：
文献类型：
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作者：
Julien Mahin;L. Torrente‐Murciano
本文提出了具有金属核的磁性Fe@Fe3O4核@壳纳米颗粒的第一连续合成，其具有对尺寸的精确控制、窄的尺寸分布和2.6g/小时的高生产速率。这种方法打开了大门，他们的部署在一系列的应用，如药物输送，分离，MRI造影剂，磁性可分离催化剂，磁热疗癌症治疗等，在连续微反应器中的关键反应参数的系统研究揭示了主要的机械步骤参与五羰基铁前体的热分解。表面活性剂的存在不仅能够使合成后的颗粒稳定化，而且还促进了前体中的初始配体交换和原位CO产生。我们表明，这种气体的生产导致在螺旋微反应器的组合迪恩-泰勒流制度。流速和反应器长度的优化导致高水平的混合和足够的停留时间（>12 s），分别导致窄的尺寸分布和高的前体转化率。
The first continuous synthesis of magnetic Fe@Fe3O4core@shell nanoparticles with a metallic core is presented herein with precise control over size, narrow size distribution and a high production rate of 2.6 g per hour. This approach opens the door to large-scale production for their deployment in a range of applications such as drug delivery, separation, MRI contrasting agents, magnetically separable catalysts, magnetic hyperthermia for cancer treatment,etc. A systematic study of key reaction parameters in continuous microreactors reveal the main mechanistic steps involved in the thermal decomposition of the iron pentacarbonyl precursor. The presence of surfactants enables not only the post-synthesis particle stabilisation but also facilitates the initial ligand exchange in the precursor and thein situCO production. We demonstrate that such gas production leads to a combined Dean-Taylor flow regime in the helical microreactors. Optimisation of the flow rate and reactor length leads to a high level of mixing and sufficient residence time (>12 s) resulting in narrow size distribution and high precursor conversion respectively.