Venlafaxine extended-release treatment of hoarding disorder.
Venlafaxine extended-release treatment of hoarding disorder.
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DOI：
10.1097/yic.0000000000000036
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发表时间：
2014-09
影响因子：
2.6
通讯作者：
Sumner J
中科院分区：
文献类型：
--
作者：
Saxena S;Sumner J
囤积症在DSM-5中被列为一种单独的疾病，是一种常见的、慢性的、可能致残的综合征，很难治疗。之前只有一项研究前瞻性地测量了强迫性囤积症患者对药物治疗的反应，发现囤积症患者对帕罗西汀的反应与非囤积强迫症患者一样好。然而，帕罗西汀在该研究中耐受性不佳，总体反应为中等。因此，我们进行了一项文拉法辛缓释治疗囤积障碍的开放标签试验，24名符合DSM-5囤积障碍标准的患者接受文拉法辛缓释治疗12周。所有患者在研究前至少6周未使用精神药物。在研究期间，不允许使用其他精神药物、认知行为疗法、组织者或清洁人员。在治疗前后分别使用储蓄清单修正量表（SI-R）和UCLA囤积严重程度量表（UHSS）来测量囤积严重程度。24例患者中有23例完成了治疗。囤积症状显著改善，UHSS评分平均下降36%，SI-R评分平均下降32%。23名完全者中有16名（70%）对文拉法辛缓释有反应。这些结果提示文拉法辛缓释治疗囤积障碍可能有效。
Hoarding Disorder, classified as a separate disorder in DSM-5, is a common, chronic, and potentially disabling syndrome that can be difficult to treat. Only one prior study prospectively measured response to pharmacotherapy in compulsive hoarders, finding that hoarders responded as well to paroxetine as did non-hoarding OCD patients. However, paroxetine was not tolerated well in that study, and overall response was moderate. Therefore, we conducted an open-label trial of venlafaxine extended-release for Hoarding Disorder. 24 patients meeting DSM-5 criteria for Hoarding Disorder were treated with venlafaxine extended-release for 12 weeks. All patients were free of psychotropic medications for at least 6 weeks prior to the study. No other psychotropic medications, cognitive-behavioral therapy, organizers, or cleaning crews were permitted during the study. To measure hoarding severity, the Saving Inventory-Revised (SI-R) and the UCLA Hoarding Severity Scale (UHSS) were administered before and after treatment. 23 of the 24 patients completed treatment. Hoarding symptoms improved significantly, with a mean 36% decrease in UHSS scores and a mean 32% decrease in SI-R scores. Sixteen of the 23 completers (70%) were classified as responders to venlafaxine extended-release. These results suggest that venlafaxine extended-release may be effective for treatment of Hoarding Disorder.