A contribution to the biology of peripheral nerves in transplantation. II. Life of peripheral nerves of mammals in plasma.
A contribution to the biology of peripheral nerves in transplantation. II. Life of peripheral nerves of mammals in plasma.
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DOI：
10.1084/jem.23.2.251
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发表时间：
1916-02-01
影响因子：
15.3
通讯作者：
Ingebrigtsen, R
中科院分区：
文献类型：
--
作者：
Ingebrigtsen, R
1.外周神经在林格液和血清中孵育后可发生沃勒氏变性，而血浆中不出现沃勒变性。2.外周神经在血浆中孵育后不能生长。沃勒变性直到第4天的周围神经也是如此。3.沃勒氏变性的周围神经从第5天开始出现雪旺合体的生长。在后来阶段的文化中，同样的结构有一个渐进的增长。可见，雪旺氏细胞的增殖是由轴突及其髓鞘的变性直接造成的。4.未见轴向柱体生长。5.雪旺合体由退变的神经生长而来，为生长轴柱在再生中的离心性取向提供了解剖学基础。6.雪旺合体与胞浆内生长的神经胶质细胞在形态上有显著相似之处。
1. The Wallerian degeneration occurring in peripheral nerves by incubation in Ringer solution and serum does not occur in plasma. 2. Peripheral nerves incubated in plasma give rise to no growth. The same is true of peripheral nerves in a Wallerian degeneration up to the 4th day. 3. Peripheral nerves in Wallerian degeneration from the 5th day give rise to a growth of the syncytium of Schwann. In cultures from later stages there is a progressive growth of the same structure. It is evident that the proliferation of the cells of Schwann is directly produced by the degeneration of the axis cylinder and its myelin sheath. 4. In no case was growth of axis cylinders observed. 5. The growth of the syncytium of Schwann from degenerating nerves affords a basis for an anatomical conception of the centrifugal orientation of growing axis cylinders in regeneration. 6. Morphologically there is a striking resemblance between the syncytium of Schwann and neuroglia growing in plasma.