Low-dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia.
Low-dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia.
复制标题
DOI：
10.1007/s00540-004-0299-4
复制
发表时间：
2005-01-01
影响因子：
2.8
通讯作者：
Kanmura, Yuichi
中科院分区：
文献类型：
--
作者：
Tsuneyoshi, Isao;Onomoto, Masanori;Kanmura, Yuichi
我们报告成功地使用低剂量加压素（VP）输注，以恢复在全身麻醉期间长时间出血后持续性低血压患者的血压危象。VP输注在两个出血后血管舒张性休克患者时，他们仍然持续水肿，尽管充分的液体复苏和药理剂量的儿茶酚胺输液。VP以0.04 U x min（-1）给药后，全身血管阻力、收缩期动脉压和尿量立即增加（与VP前即刻获得的值相比），并且可减少儿茶酚胺的输注。在这些患者中，VP输注期间未观察到不良心脏影响。在长时间和严重出血后的血管舒张性休克期间，VP似乎可有效逆转低血压，减少对外源性儿茶酚胺的需求，同时保留心脏功能和关键器官血流。
We report the successful use of a low-dose vasopressin (VP) infusion to recover a hypotensive crisis in patients who suffered persistent hypotension after prolonged hemorrhage during general anesthesia. VP was infused in two posthemorrhagic vasodilatory shock patients when they remained persistently hypotensive despite adequate fluid resuscitation and infusions of pharmacological doses of catecholamines. On administration of VP at 0.04 U x min(-1), systemic vascular resistance, systolic arterial pressure, and urine output were immediately increased (as compared with the values obtained just before VP), and infusion of catecholamine could be decreased. No adverse cardiac effects were observed during VP infusions in these patients. During vasodilatory shock after prolonged and severe hemorrhage, VP seems to be effective in reversing hypotension and decreasing the need for exogenous cathecholamines while preserving cardiac function and critical organ blood flow.