The effect of Timolol 0.5% on the correction of myopic regression after LASIK.
The effect of Timolol 0.5% on the correction of myopic regression after LASIK.
复制标题
%20效果%20of%20噻吗洛尔%200.5%%20on%20%20矫正%20of%20近视%20回归%20after%20LASIK
DOI：
10.1097/md.0000000000006782
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发表时间：
2017-04
期刊：
影响因子：
1.6
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Qi H;Gao C;Li Y;Feng X;Wang M;Zhang Y;Chen Y
背景：LASIK术后屈光性消退被定义为初始矫正的逐渐、部分或全部丧失，这限制了LASIK手术的可预测性、效率和长期稳定性。本研究评估0.5%替莫洛尔对LASIK术后近视消退的矫正效果。方法：本前瞻性、随机、对照研究纳入62例近视LASIK术后近视退行度为- 1.18±0.86屈光度(D)的患者62只眼。他们被随机分为两组，第一组使用0.5%的替莫洛尔滴眼液3个月，第二组使用人工泪液作为对照（治疗期间）。患者在停止滴眼液治疗后再随访2个月（治疗后）。结果：第一组在治疗过程中，随着平均真眼压（IOPT）明显降低，消退停止。当平均IOPT在治疗后显著增加并恢复到治疗前水平时，回归复发。替洛尔治疗有效率由治疗期间的62.5%下降至治疗后的40.6%。相反，在第二组中，虽然平均IOPT没有明显变化，但随着时间的推移，持续出现回归。治疗期间，两组患者的平均IOPT、未矫正视力、球等效（SE）、角膜屈光度数均有显著性差异。在组1中，年龄、性别、术前SE （PSE）、预处理时间（lasik术后开始使用替洛尔的时间）两个亚组间替洛尔治疗有效率的差异无统计学意义。结论：降眼压滴眼液替马洛尔对于LASIK术后近视移位0.5 d及以上的患者，不论年龄、性别、PSE，或仅因近视消退而开始治疗，均可有效矫正近视消退。然而，停止替马洛尔治疗后近视复发。
Backgroud: Postlaser in situ keratomileusis (post-LASIK) refractive regression is defined as the gradual, partial, or total loss of initial correction that limits the predictability, efficiency, and long-term stability of LASIK. Our study assesses the effect of Timolol 0.5% on the correction of myopic regression after LASIK. Methods: This prospective, randomized, controlled study included 62 eyes of 62 patients with myopic regression of −1.18 ± 0.86 diopters (D) after myopic LASIK. They were randomly assigned into either Group 1 who received Timolol 0.5% eye drops for 3 months or Group 2 who received artificial tears as control (during treatment). Patients were followed an additional 2 months after cessation of eye drops treatment (posttreatment). Results: During treatment in Group 1, as the mean true intraocular pressure (IOPT) lowered significantly, regression stopped. As the mean IOPT increased significantly posttreatment and returned to its pretreatment level, regression recurred. The effective rate of Timolol therapy dropped from 62.5% during treatment to 40.6% posttreatment. On the contrary in Group 2, although the mean IOPT did not change significantly, regression continually happened as time passed. During treatment, the mean IOPT, uncorrected visual acuity, spherical equivalent (SE), and corneal refractive power showed significant difference between the 2 groups. In Group 1, the differences of effective rate of Timolol therapy between each of the 2 subgroups of age, gender, preoperative SE (PSE), or pretreatment time (how long we start treatment with Timolol post-LASIK) were not statistically significant. Conclusion: IOP-lowering eye drop Timolol was effective for the correction of myopic regression when a 0.5-D or greater myopic shift is detected after LASIK in patients regardless of age, gender, PSE, or anytime we started the treatment only if regression happened. However, the myopic regression recurred after cessation of Timolol treatment.