Plasma homocysteine is associated with the risk of mild cognitive impairment in an elderly Korean population
Plasma homocysteine is associated with the risk of mild cognitive impairment in an elderly Korean population
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DOI：
10.1093/jn/137.9.2093
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发表时间：
2007-09-01
影响因子：
4.2
通讯作者：
Jo, Inho
中科院分区：
文献类型：
--
作者：
Kim, Jihye;Park, Moon Ho;Jo, Inho
患有轻度认知障碍（MCI）的老年人患痴呆症（包括阿尔茨海默病）的风险很高。以往的研究表明，血浆同型半胱氨酸水平升高可能是痴呆的一个危险因素。然而，血浆同型半胱氨酸对MCI的影响仍然存在争议。我们调查了高同型半胱氨酸血症与韩国老年人群MCI风险之间的关系。从安山老年医学研究中共选择1215例老年受试者（年龄60-85岁）参与本研究。根据马约诊所标准诊断MCI。MCI老年患者血浆同型半胱氨酸浓度高于正常老年患者（17.6 +/-7.4 vs. 15.7 +/-4.8 μ mol/L; P < 0.001）。高同型半胱氨酸血症（>15 μ mol/L）的受试者也有较高的MCI患病率。高同型半胱氨酸血症患者MCI的未校正OR值高于正常人，且随高同型半胱氨酸血症程度的增加而增加（OR = 1.39，95%CI = 1.09 ~ 1.79 vs. OR = 2.61，95%CI = 1.22-5.61）。在调整了年龄、性别和其他认知功能障碍的假定风险因素后，这些趋势没有差异（OR = 1.40; 95% CI = 1.07-1.83 vs. OR = 2.40; 95% CI = 1.08-5.31）。总之，高同型半胱氨酸血症可能是韩国老年人MCI的独立危险因素。血浆同型半胱氨酸水平和认知功能障碍之间的因果关系应在韩国老年受试者的随访研究中进行评估。
Elderly individuals with mild cognitive impairment (MCI) are at high risk for developing dementia, including Alzheimer's disease. Previous studies have proposed that elevated plasma homocysteine might be a risk factor for dementia. However, the impact of plasma homocysteine on MCI remains controversial. We investigated the relation between hyperhomocysteinemia and the risk of MCI in an elderly Korean population. A total of 1215 elderly subjects (aged 60-85 y) were selected from the Ansan Geriatric study to participate in this study. MCI was diagnosed on the basis of the Mayo Clinic criteria. Mean plasma homocysteine concentrations were higher in elderly subjects with MCI than in normal elderly subjects (17.6 +/-_ 7.4 vs. 15.7 +/-_ 4.8 mu mol/L; P < 0.001). Subjects with hyperhomocysteinemia (>15 mu mol/L) also had a higher prevalence of MCI. The unadjusted OR for MCI was greater in subjects with hyperhomocysteinemia than in normal subjects and it increased according to the degree of hyperhomocysteinemia (OR = 1.39, 95% CI = 1,09-1.79 vs. OR = 2.61; 95% CI = 1.22-5.61). These trends did not differ after adjustment for age, sex, and other putative risk factors for cognitive dysfunction (OR = 1.40; 95% CI = 1.07-1.83 vs. OR = 2.40; 95% CI = 1.08-5.31). In conclusion, hyperhomocysteinemia may be an independent risk factor for MCI in elderly Koreans. A causal relationship between plasma homocysteine levels and cognitive impairment should be evaluated in a follow-up study of elderly Korean subjects.