CORTICAL AND THALAMIC AFFERENT CONNECTIONS OF THE INSULAR AND ADJACENT CORTEX OF THE RAT
CORTICAL AND THALAMIC AFFERENT CONNECTIONS OF THE INSULAR AND ADJACENT CORTEX OF THE RAT
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DOI：
10.1002/cne.902150203
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
MARKOWITSCH, HJ
中科院分区：
文献类型：
--
作者：
GULDIN, WO;MARKOWITSCH, HJ
研究了大鼠岛叶和鼻周皮层的丘脑和皮质传入神经。沿鼻沟进行离子电渗疗法单侧注射辣根过氧化物酶（HRP）。 HRP 注射覆盖或侵入沿鼻裂的区域，从大脑中动脉水平到鼻裂后端。最前面的注射标记了内侧核中的一些细胞。更多的后部注射标记了腹内侧核基底部分的神经元，表明该皮质区域构成了大鼠的味觉（岛叶）皮质。位于鼻沟内和上方味觉皮层后方的皮层被认为是大鼠（联合）岛叶皮层的核心区域，因为它接收来自膝状上核和内侧核、大细胞部核的区域和之间的传入神经。它包括其他研究中称为鼻周的皮质部分。岛叶皮质的背侧和后侧皮质被认为是听觉皮质，因为它接收来自内侧膝状核主要部分的传入信号。岛叶皮质腹侧的皮质（鼻沟基底下方）被认为构成梨状皮层，属于丘脑。鼻周皮层的后部（区域 35）接收来自非特异性丘脑核（中线核）的传入信号。注射位点的皮质传入来自许多区域，首先是内侧和脑沟前额叶皮质区域。这些注射仅限于膝上大细胞内侧膝状核复合体的投射皮层，也导致对侧前额叶区域的标记，特别是在区域 25（边缘下区域）。将结果与猫和猴子岛叶皮质的结果进行比较表明，根据丘脑皮质连接、地形关系以及神经元参与信息处理和外显行为，岛叶皮质必须被视为异质区域，可以分为前额岛叶、味觉（体感）岛叶和联想岛叶部分。
Thalamic and cortical afferents to the insular and perirhinal cortex of the rat were investigated. Unilateral injections of horseradishe peroxidase (HRP) were made iontophoretically along the rhinal sulcus. HRP injections covered or invaded areas along the rhinal fissure from about the level of the middle cerbral artery to the posterior end of the fissure. The most anterior injection labeled a few cells in the mediodorsal nucleus. More posterior injections labeled neurons in the basal portion of the nucleus ventralis medialis, suggesting that this cortical region constitutes the rat''s gustatory (insular) cortex. The cortex situated posterior to the gustatory cortex in and above the rhinal sulcus is considered the core region of the rat''s (associative) insular cortex, as it receives afferents from the regions of and between the nuclei suprageniculatus and geniculatus medialis, pars magnocellularis. It includes parts of the cortex termed perirhinal in other studies. The cortex dorsal and posterior to the insular cortex is considered the auditory cortex, as it receives afferents from the principal part of the medial geniculate nucleus. The cortex ventral to the insular cortex (below the fondus of the rhinal sulcus) is considered to constitute the prepiriform cortex, which is athalamic. The posterior part of the perirhinal cortex (area 35) receives afferents from nonspecific thalamic nuclei (midline nuclei). Cortical afferents to the injection loci arise from a number of regions, above all from regions of the medial and sulcal prefrontal cortex. Those injections confined to the projection cortex of the suprageniculate-magnocellular medial geniculate nuclear complex also led to labeling in contralateral prefrontal regions, particularly in area 25 (infralimbic region). A comparison of the results with those on the insular cortex of cats and monkeys suggests that on the basis of thalamocortical connections, topographic relations, and involvements of neurons in information processing and overt behavior, the insular cortex has to be regarded as a heterogeneous region which may be separated into prefrontal insular, gustatory (somatosensory) insular and associative insular portions.