Comparison of Two Inflammation-Based Prognostic Scores in Patients with Unresectable Advanced Gastric Cancer
Comparison of Two Inflammation-Based Prognostic Scores in Patients with Unresectable Advanced Gastric Cancer
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DOI：
10.1159/000342376
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发表时间：
2012-01-01
期刊：
影响因子：
3.5
通讯作者：
Kim, Yu Ri
中科院分区：
文献类型：
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作者：
Jeong, Jae-Heon;Lim, Sun Min;Kim, Yu Ri
目的：本研究的目的是比较两种基于炎症的预后评分（中性粒细胞与淋巴细胞比率（NLR）和改良格拉斯哥预后评分（mGPS））在诊断IV期进展期胃癌（AGC）时的有效性。方法：回顾性分析104例初治转移性AGC患者姑息性化疗的临床资料。结果如下：在单变量分析中，以下变量与较短的总生存期（OS）相关：组织学差或未分化（p = 0.013），超过1处转移（p = 0.004），淋巴结转移的存在（p = 0.003），骨转移的存在（p = 0.019），较低的白蛋白水平（p < 0.001），C反应蛋白升高（p < 0.001）、高中性粒细胞绝对计数（p = 0.016）、NLR >= 3（p < 0.001）和较高的mGPS（分别为p < 0.001和p = 0.007）。在多变量分析中，高NLR和mGPS是较短OS的独立预后因素（分别为p = 0.037，p < 0.001和p = 0.010），沿着淋巴结转移（p = 0.005）和组织学亚型（p = 0.048）。结论：这项研究表明，炎症标志物，NLR和mGPS，是姑息化疗治疗的不可切除AGC患者OS的独立预后因素。版权所有（C）2012 S. Karger AG，巴塞尔
Objectives: The objective of this study was to compare the usefulness of two inflammation-based prognostic scores, neutrophil to lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS), assessed at diagnosis in stage IV advanced gastric cancer (AGC). Methods: We retrospectively reviewed the medical records of 104 patients with newly diagnosed metastatic AGC treated with palliative chemotherapy. Results: In the univariate analysis, the following variables were associated with shorter overall survival (OS): poor or undifferentiated histology (p = 0.013), more than 1 metastasis (p = 0.004), the presence of lymph node metastasis (p = 0.003), the presence of bone metastasis (p = 0.019), a lower albumin level (p < 0.001), elevated C-reactive protein (p < 0.001), a high absolute neutrophil count (p = 0.016), NLR >= 3 (p < 0.001) and higher mGPS (p < 0.001 and p = 0.007, respectively). In the multivariate analysis, high NLR and mGPS were independent prognostic factors for shorter OS (p = 0.037, p < 0.001 and p = 0.010, respectively), along with lymph node metastasis (p = 0.005) and histological subtype (p = 0.048). Conclusion: This study suggests that the inflammatory markers, NLR and mGPS, are independent prognostic factors for OS in patients with unresectable AGC treated with palliative chemotherapy. Copyright (C) 2012 S. Karger AG, Basel