Antituberculosis drug resistance and anonymous HIV surveillance in tuberculosis patients in Botswana, 2002
Antituberculosis drug resistance and anonymous HIV surveillance in tuberculosis patients in Botswana, 2002
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DOI：
10.1016/s0140-6736(05)67062-6
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发表时间：
2005-08-06
期刊：
影响因子：
168.9
通讯作者：
Wells, CD
中科院分区：
文献类型：
--
作者：
Nelson, LJ;Talbot, EA;Wells, CD
尽管自 1989 年以来，博茨瓦纳的结核病发病率增加了三倍，但 20 世纪 90 年代在博茨瓦纳进行的两项调查显示，抗结核药物耐药率较低。我们进行了第三次调查，以确定 1995 年以来的趋势以及博茨瓦纳结核病患者中的艾滋病毒流行情况。 2002 年，我们从全国范围内的患者身上采集了痰标本，这些患者还使用 Oraquick 进行了匿名、快速的 HIV 检测。在 2200 名痰涂片阳性患者和 219 名既往治疗过的疑似复发性结核病患者中，1457 名（60%）感染了 HIV。新患者中对至少一种药物的耐药性从 1995 年的 16 个分离株 (3.7%) 增加到 123 个分离株 (10.4%；p
Two surveys undertaken in Botswana in the 1990s have recorded low rates of antituberculosis drug resistance, despite a three-fold rise in tuberculosis since 1989. We under-took a third survey to determine both trends since 1995 and HIV prevalence in tuberculosis patients in Botswana. Sputum specimens were obtained from patients nationwide in 2002 who also underwent anonymous, rapid HIV testing by use of Oraquick. Of 2200 sputum smear-positive patients and 219 previously treated patients with suspected recurrent tuberculosis, 1457 (60%) were infected with HIV. Resistance to at least one drug in new patients rose from 16 (3.7%) isolates in 1995 to 123 (10.4%; p