Selective detection of catecholamines by synthetic receptors embedded in chromatic polydiacetylene vesicles
Selective detection of catecholamines by synthetic receptors embedded in chromatic polydiacetylene vesicles
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DOI：
10.1021/ja052436q
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发表时间：
2005-07-20
影响因子：
15
通讯作者：
Jelinek, R
中科院分区：
文献类型：
--
作者：
Kolusheva, S;Molt, O;Jelinek, R
通过将合成受体嵌入包含磷脂和聚二乙炔的囊泡中，构建了一种新的儿茶酚胺检测方案。聚二乙炔的荧光发射是通过可溶性配体和囊泡掺入的宿主之间的特异性相互作用诱导的。该系统在结构相似的配体中表现出显着的选择性，并且与其他报道的儿茶酚胺传感器相比，实现了低得多的检测阈值。染色组装提供了配体-受体相互作用的高灵敏度检测的通用途径。
A new detection scheme for catecholamines was constructed through embedding synthetic receptors within vesicles comprising phospholipids and polydiacetylene. Fluorescence emission of the polydiacetylene was induced through specific interactions between the soluble ligands and the vesicle-incorporated hosts. The system demonstrated remarkable selectivity among structurally similar ligands and achieved much lower detection thresholds compared to that of other reported catecholamine sensors. The chromatic assembly provides a generic route for high sensitivity detection of ligand−receptor interactions.