SHORT-TERM OR LONG-TERM INTRACEREBROVENTRICULAR (ICV) INFUSION OF INSULIN EXHIBITS A DISCRETE ANABOLIC EFFECT ON CEREBRAL ENERGY-METABOLISM IN THE RAT
SHORT-TERM OR LONG-TERM INTRACEREBROVENTRICULAR (ICV) INFUSION OF INSULIN EXHIBITS A DISCRETE ANABOLIC EFFECT ON CEREBRAL ENERGY-METABOLISM IN THE RAT
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DOI：
10.1016/0304-3940(94)91102-9
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发表时间：
1994-07-04
影响因子：
2.5
通讯作者：
HOYER, S
中科院分区：
文献类型：
--
作者：
HENNEBERG, N;HOYER, S
胰岛素参与脑糖酵解葡萄糖催化剂调节的证据越来越令人信服。为了研究短期或长期给予胰岛素是否会影响大脑能量代谢，我们测定了脑室内（i. c. v.）激素输注1、7和21天。在大脑顶颞叶皮层，ATP、PCr、ADP、ATP/ADP比值和能荷电位均无变化。而海马PCr浓度则显著升高。因此，短期和长期静脉注射胰岛素被认为对大脑能量库具有离散的合成代谢作用。
Evidence for an involvement of insulin in the regulation of cerebral glycolytic glucose catabolism is becoming more and more convincing. To investigate whether short-term or long-term administration of insulin to the brain influences brain energy metabolism, we determined tissue concentrations of energy-rich phosphates in cerebral parietotemporal cortex and in hippocampus of 1- (adult) and 2-year-old (aged) male Wistar rats treated with intracerebroventricular (i.c.v.) infusion of the hormone for 1, 7, and 21 days. In cerebral parietotemporal cortex, tissue concentrations of ATP, PCr, ADP, ATP/ADP ratio and energy charge potential were all unaltered. In hippocampus, however, the concentration of PCr was significantly increased. Thus, short-term and long-term i.c.v. administration of insulin are assumed to have a discrete anabolic effect on the cerebral energy pool.