ONE SHORT WELL CONSERVED REGION OF ALU-SEQUENCES IS INVOLVED IN HUMAN GENE REARRANGEMENTS AND HAS HOMOLOGY WITH PROKARYOTIC-CHI
ONE SHORT WELL CONSERVED REGION OF ALU-SEQUENCES IS INVOLVED IN HUMAN GENE REARRANGEMENTS AND HAS HOMOLOGY WITH PROKARYOTIC-CHI
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DOI：
10.1093/nar/23.2.256
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发表时间：
1995-01-25
影响因子：
14.9
通讯作者：
KIELLANDBRANDT, MC
中科院分区：
文献类型：
--
作者：
RUDIGER, NS;GREGERSEN, N;KIELLANDBRANDT, MC
Alu元件已多次被发现参与人类基因重排。虽然这些元素已被建议刺激基因重排，稀疏的信息是这些事件的可能机制（S）。在这里，我们提出了一个汇编的Alu元素，已参与重组事件导致基因重排，表明存在一个共同的26 bp的核心序列或接近重组的网站。除了反转录转座的明显可能性外，基因重排也可能由刺激基因重组的序列诱导。我们认为，核心序列刺激重组，从而可能导致这些元素在基因重排的频繁参与。奇怪的是，核心序列包含五核苷酸基序CCAGC，它也是chi的一部分，chi是一个已知刺激大肠杆菌中recBC介导的重组的8 bp序列。
Alu elements have repeatedly been found involved in gene rearrangements in humans. Although these elements have been suggested to stimulate gene rearrangements, sparse information is available for the possible mechanism(s) of these events. Here we present a compilation of Alu elements that have been involved in recombinational events leading to gene rearrangements, indicating the presence of a common 26 bp core sequence at or close to the sites of recombination. Besides the obvious possibility of retrotransposition, gene rearrangements may be induced by sequences that stimulate genetic recombination. We suggest that the core sequence stimulates recombination and may thereby cause the frequent involvement of these elements in gene rearrangements. Curiously, the core sequence contains the pentanucleotide motif CCAGC, which is also part of chi, an 8 bp sequence known to stimulate recBC mediated recombination in Escherichia coli.