Catalysis of fluorine addition to double bond: An improvement of method for synthesis of 18F PET agents
Catalysis of fluorine addition to double bond: An improvement of method for synthesis of 18F PET agents
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DOI：
10.1016/j.apradiso.2009.10.005
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发表时间：
2010-02-01
影响因子：
1.6
通讯作者：
Koch, Cameron J.
中科院分区：
文献类型：
--
作者：
Kachur, Alexander V.;Dolbier, William R., Jr.;Koch, Cameron J.
描述了亲电氟加成至氟化双键的反应的催化。少量碘、溴或三氟化硼的存在增加了总产物产率和氟掺入程度，使得该反应成为制备F-18正电子发射断层扫描剂的更有效方法。讨论了碘催化作用的可能机制。 (C) 2009 Elsevier Ltd. 保留所有权利。
Catalysis for reaction of electrophilic fluorine addition to a fluorinated double bond is described. The presence of small amounts of iodine, bromine, or boron trifluoride increases an overall product yield and degree of fluorine incorporation, making the reaction a more efficient method for preparation of F-18 positron emission tomography agents. A possible mechanism of catalytic action of iodine is discussed. (C) 2009 Elsevier Ltd. All rights reserved.