The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens
The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens
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DOI：
10.1086/422002
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发表时间：
2004-07-15
影响因子：
11.8
通讯作者：
Donskey, CJ
中科院分区：
文献类型：
--
作者：
Donskey, CJ
肠道为许多医院病原体提供了重要的储存库，包括肠球菌属、肠杆菌属、艰难梭菌和念珠菌属。这些微生物有几个共同的风险因素，并且经常共存于肠道中。正常屏障的破坏，如胃酸和结肠的固有微生物区系，促进病原体的过度生长。大便失禁和腹泻等因素导致病原体随后传播到卫生保健环境中。由抗生素施加的选择压力在病原体定殖中起着特别重要的作用，并且与这些药剂相关的不良反应通常持续超过治疗期。为控制单个病原体而实施的预防控制措施可能对控制肠道定植的其他病原体的努力产生积极或消极的影响。
The intestinal tract provides an important reservoir for many nosocomial pathogens, including Enterococcus species, Enterobacteriaciae, Clostridium difficile, and Candida species. These organisms share several common risk factors and often coexist in the intestinal tract. Disruption of normal barriers, such as gastric acidity and the indigenous microflora of the colon, facilitates overgrowth of pathogens. Factors such as fecal incontinence and diarrhea contribute to the subsequent dissemination of pathogens into the health care environment. Selective pressure exerted by antibiotics plays a particularly important role in pathogen colonization, and adverse effects associated with these agents often persist beyond the period of treatment. Infection-control measures that are implemented to control individual pathogens may have a positive or negative impact on efforts to control other pathogens that colonize the intestinal tract.