Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile α,β-Unsaturated Amino Ketones
Highly Chemoselective Copper-Catalyzed Conjugate Reduction of Stereochemically Labile α,β-Unsaturated Amino Ketones
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DOI：
10.1021/jo9017588
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发表时间：
2009-10-02
影响因子：
3.6
通讯作者：
Koskinen, Ari M. P.
中科院分区：
文献类型：
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作者：
Pelss, Andrejs;Kumpulainen, Esa T. T.;Koskinen, Ari M. P.
通过使用亚磷酸三异丙酯连接的氢化铜络合物，开发了手性 α,β-不饱和氨基酮的高度化学选择性共轭还原。该方法的亮点是广泛的底物兼容性和卓越的化学选择性。
Highly chemoselective conjugate reduction of chiral alpha,beta-unsaturated amino ketones has been developed by using triisopropyl phosphite ligated copper hydride complex. The highlights of the method are wide substrate compatibility and exceptional chemoselectivity.