The Serological Classification of Corynebacterium Equi
The Serological Classification of Corynebacterium Equi
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马棒状杆菌的血清学分类
DOI：
10.1093/infdis/65.1.92
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发表时间：
1939
期刊：
影响因子：
--
通讯作者：
P. R. Edwards
中科院分区：
文献类型：
--
作者：
D. W. Bruner;W. W. Dimock;P. R. Edwards
马棒状杆菌是马驹肺炎的一种病原体，由于该微生物的生物化学活性相对较低，因此在鉴定马棒状杆菌时存在一定的困难。当从马的肺脓肿中分离出产生大的潮湿菌落和棕褐色色素的囊化类白喉时，毫无疑问涉及的细菌是C。马，因为由生物体产生的病理变化是相当典型的。然而，当从流产的马胎儿、不育的马的生殖道或从其他家畜的各种病理状态中分离出类似的杆菌时，人们就不愿意把这种生物体归为C.这仅仅是由于形态和文化的相似性。由于该物种既不从碳水化合物中产生酸也不产生气体，也不产生任何其他生化变化，这些变化有助于将其与其他显色类白喉区分开来，因此识别它存在困难。为了建立一种令人满意的鉴定方法，对该杆菌进行了血清学研究。关于棒状杆菌的血清学特征的研究相对较少。罗宾逊和Peeney 1总结了C.白喉这些工作人员发现，有可能将白喉杆菌分为许多在流行病学上具有重要意义的凝集型。Brown和Orcut发现C.他们研究的化脓菌在沉淀试验中都产生了交叉反应。某些菌株的反应强度表明了抗原性差异，但未进行吸收试验。Magnusson3用C.等。只有一匹马的凝集素滴度符合要求。他所分离的所有培养物，以及由澳大利亚的Bull4分离的培养物，都能被这匹马的血清同样良好地凝集。
The identification of Corynebacterium equi, an etiologic agent of pneumonia in foals, offers some difficulty because of the comparative biochemical inactivity of the micro-organism. When encapsulated diphtheroids that produce large moist colonies and a tan pigment are isolated from pulmonary abscesses in horses, there can be little doubt that the bacteria involved are C. equi since the pathological changes produced by the organisms are quite characteristic. When, however, similar bacilli are isolated from aborted equine fetuses, from the genital tracts of barren mares or from various pathological conditions in other species of domestic animals; one hesitates to classify the organisms as C. equi merely on account of morphological and cultural similarity. Inasmuch as this species produces neither acid nor gas from carbohydrates nor gives rise to any other biochemical changes which serve to differentiate it from other chromogenic diphtheroids, its recognition presents difficulties. In an attempt to establish a satisfactory method of identification a serological study of the bacillus was undertaken. Comparatively little work has been done on the serological characteristics of the Corynebacteria. Robinson and Peeney1 summarized the results obtained in the study of C. diphtheriae. These workers found it possible to divide the diphtheria bacillus into a number of agglutinative types which were epidemiologically significant. Brown and Orcutt2 found that the cultures of C. pyogenes which they studied all gave cross reactions in precipitation tests. Antigenic differences were indicated by the intensity of the reactions of certain strains but absorption tests were not performed. Magnusson3 injected two horses with a culture of C. equi. Only one of the horses developed a satisfactory agglutinin titer. All the cultures which he had isolated, as well as a culture isolated by Bull4 in Australia, were agglutinated equally well by the serum of this horse.