Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders
Habitual binge/purge behavior influences circulating ghrelin levels in eating disorders
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DOI：
10.1016/s0022-3956(02)00067-5
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发表时间：
2003-01-01
影响因子：
4.8
通讯作者：
Nozoe, S
中科院分区：
文献类型：
--
作者：
Tanaka, M;Naruo, T;Nozoe, S
以往的研究报道空腹血浆胃饥饿素浓度在饮食失调的病理生理中起重要作用。本研究的目的是探讨血浆胃饥饿素水平与异常饮食行为频率、饮食失调的营养参数之间的关系。在积极治疗开始前，采集女性神经性厌食症（AN）患者40例、限制型（AN- r）患者21例、暴食/泻型（AN- bp）患者19例、神经性贪食（BN）患者31例、泻型（BN- p）患者18例、非泻型（BN- np）患者13例、女性健康志愿者15例（对照）的空腹血样。所有受试者的空腹血浆胃饥饿素浓度与体重指数、体脂百分比和血清胆碱酯酶浓度等营养参数呈负相关。尽管营养参数相似，但BN-NP组的平均血浆胃饥饿素水平高于BN-NP组和对照组。尽管营养参数不同，AN-R和AN-BP组的血浆胃饥饿素水平与BN-P组没有差异。对于有习惯性暴食/排便行为的AN-BP和BN-P患者，血浆胃饥饿素值、暴食/排便周期频率和血清淀粉酶值之间存在显著相关性。在BN-NP中，血浆胃饥饿素值、暴食发作频率和血清淀粉酶值之间无显著相关性。这些结果表明，习惯性暴食/清除行为可能对循环血浆中BN-P和AN-BP的胃饥饿素水平有一定影响。与无呕吐的暴食发作相比，伴有呕吐的习惯性暴食/排便周期可能对进食障碍患者的空腹血浆胃饥饿素浓度有更大的影响。(C) 2002 Elsevier Science Ltd.版权所有。
Previous studies have reported that fasting plasma ghrelin concentrations play an important role in the pathophysiology of eating disorders. The purpose of this study was to examine the relationship between plasma ghrelin levels and frequency of abnormal eating behaviors, nutritional parameters in eating disorders. Fasting blood samples were obtained in 40 female anorexia nervosa (AN) patients, 21 restricting type (AN-R) and 19 binge-eating/purging type (AN-BP), in 31 bulimia nervosa (BN) patients, 18 purging type (BN-P) and 13 nonpurging type (BN-NP), in 15 female healthy volunteers (control) before the initiation of active treatment. The fasting plasma ghrelin concentrations in all subjects were negatively correlated with nutritional parameters such as body mass index, percent body fat and serum cholinesterase concentration. The mean plasma ghrelin level in BN-P was higher than that in both BN-NP and controls despite similar nutritional parameters. The plasma ghrelin levels in both AN-R and AN-BP did not differ from BN-P despite difference of nutritional parameters. For both AN-BP and BN-P patients with habitual binge/purge behavior, there were significant correlations among plasma ghrelin values, frequencies of binge/purge cycles and serum amylase values. In BN-NP, there were no significant correlations among plasma ghrelin values, frequencies of binge-eating episodes and serum amylase values. These results suggest that habitual binge/purge behavior may have some influence on circulating plasma ghrelin levels in both BN-P and AN-BP. Habitual binge/purge cycles with vomiting as opposed to binge-eating episodes without vomiting may have a greater influence on fasting plasma ghrelin concentration in eating disorders. (C) 2002 Elsevier Science Ltd. All rights reserved.