Estrogen/ER in anti-tumor immunity regulation to tumor cell and tumor microenvironment.
Estrogen/ER in anti-tumor immunity regulation to tumor cell and tumor microenvironment.
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雌激素/ER对肿瘤细胞和肿瘤微环境的抗肿瘤免疫调节作用
DOI：
10.1186/s12935-021-02003-w
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发表时间：
2021-06-07
影响因子：
5.8
通讯作者：
Yu W
中科院分区：
文献类型：
--
作者：
Wang T;Jin J;Qian C;Lou J;Lin J;Xu A;Xia K;Jin L;Liu B;Tao H;Yang Z;Yu W
雌激素及其受体作为人体必需的性激素，已被证明参与自身免疫性疾病和抗肿瘤免疫的调节。肿瘤免疫的调节与癌细胞、免疫细胞和肿瘤微环境之间的相互作用有关，它们被认为是雌激素诱导的免疫系统调节的潜在靶点。然而，雌激素诱导免疫的具体机制尚不清楚。通常，雌激素会导致雌激素/雌激素受体复合物的核定位并改变靶基因的转录模式，从而导致肿瘤细胞的重编程和免疫细胞的分化。然而，雌激素诱导的非经典信号通路激活对于雌激素的快速发挥作用也至关重要，如NF-κB、MAPK-ERK和β-catenin通路激活，但尚未完全阐明。因此，研究这两种方式的雌激素调节机制对于肿瘤免疫至关重要，并且可以为内分泌激素靶向癌症免疫治疗提供潜力。本文对雌激素诱导的经典和非经典信号转导通路进行综述，旨在重点探讨雌激素与癌症免疫的关系以及免疫相关的肿瘤微环境调节。这些临床前研究结果阐明了雌激素靶向治疗具有癌症免疫治疗的应用前景，需要对这些治疗策略进行进一步的转化研究。
As the essential sexual hormone, estrogen and its receptor has been proved to participate in the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor immunity is related to the interaction between cancer cells, immune cells and tumor microenvironment, all of which is considered as the potential target in estrogen-induced immune system regulation. However, the specific mechanism of estrogen-induced immunity is poorly understood. Typically, estrogen causes the nuclear localization of estrogen/estrogen receptor complex and alternates the transcription pattern of target genes, leading to the reprogramming of tumor cells and differentiation of immune cells. However, the estrogen-induced non-canonical signal pathway activation is also crucial to the rapid function of estrogen, such as NF-κB, MAPK-ERK, and β-catenin pathway activation, which has not been totally illuminated. So, the investigation of estrogen modulatory mechanisms in these two manners is vital for the tumor immunity and can provide the potential for endocrine hormone targeted cancer immunotherapy. Here, this review summarized the estrogen-induced canonical and non-canonical signal transduction pathway and aimed to focus on the relationship among estrogen and cancer immunity as well as immune-related tumor microenvironment regulation. Results from these preclinical researches elucidated that the estrogen-target therapy has the application prospect of cancer immunotherapy, which requires the further translational research of these treatment strategies.
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