Physical Performance and Frailty in Chronic Kidney Disease
Physical Performance and Frailty in Chronic Kidney Disease
复制标题
DOI：
10.1159/000355568
复制
发表时间：
2013-01-01
影响因子：
4.2
通讯作者：
Leonard, Mary B.
中科院分区：
文献类型：
--
作者：
Reese, Peter P.;Cappola, Anne R.;Leonard, Mary B.
背景：身体机能差和虚弱与死亡和残疾的风险增加有关。慢性肾脏疾病（CKD）也与这些结果密切相关。然而，CKD患者身体表现差和虚弱的风险尚未得到很好的证实。方法：我们测量了1111名慢性肾功能不全队列参与者的短体能测试（SPPB；步态速度，椅子上升和平衡的综合测试；范围0-12）和虚弱的五要素。调整人口统计学和多种合并症，我们拟合SPPB评分结果的线性回归模型和虚弱状态的有序逻辑回归模型。结果：中位（四分位间距，IQR）年龄为65（57-71）岁，非透析患者肾小球滤过率（eGFR）中位估计为49 (36-62)ml/min/1.73 m(2)， SPPB评分中位为9（7-10）。7%的参与者身体虚弱，43%的参与者身体虚弱。与eGFR 60 ml/min/1.73 m(2)的SPPB评分相比，eGFR 30-59的SPPB评分低0.51分；15-29岁的eGFR下降0.61点，eGFR下降1.75点
Background: Poor physical performance and frailty are associated with elevated risks of death and disability. Chronic kidney disease (CKD) is also strongly associated with these outcomes. The risks of poor physical performance and frailty among CKD patients, however, are not well established. Methods: We measured the Short Physical Performance Battery (SPPB; a summary test of gait speed, chair raises and balance; range 0-12) and the five elements of frailty among 1,111 Chronic Renal Insufficiency Cohort participants. Adjusting for demographics and multiple comorbidities, we fit a linear regression model for the outcome of SPPB score and an ordinal logistic regression model for frailty status. Results: Median (interquartile range, IQR) age was 65 (57-71) years, median estimated glomerular filtration rate (eGFR) for non-dialysis patients was 49 (36-62) ml/min/1.73 m(2), and median SPPB score was 9 (7-10). Seven percent of participants were frail and 43% were pre-frail. Compared with the SPPB score for eGFR >60 ml/min/1.73 m(2), the SPPB was 0.51 points lower for eGFR 30-59; 0.61 points lower for eGFR 15-29, and 1.75 points lower for eGFR