Role of electromechanical and mechanoelectric effects in protein hydration under hydrostatic pressure.
Role of electromechanical and mechanoelectric effects in protein hydration under hydrostatic pressure.
复制标题
机电和机电效应在静水压力下蛋白质水合中的作用。
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
A. Ferchmin
中科院分区：
文献类型：
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作者：
I. Danielewicz;E. Banachowicz;A. Ferchmin
最近对非变性压力下溶菌酶水合水密度的测量表明，它高于相同条件下的本体水密度。早先在环境条件下观察到高蛋白质水合层密度，并归因于电致伸缩。我们计算了压力诱导的蛋白质平均表面电荷密度增量Δσ。在水化层内，由于Δσ导致的较高场通过电致伸缩导致额外的水压缩。增量Δσ被认为是由于蛋白质分子中的机械电效应。计算了有效力电系数d的平均值，并与氨基酸及其化合物的压电系数进行了比较。
Recent measurements of lysozyme hydration water density under non-denaturing pressure show that it is higher than that of bulk water in the same conditions. High protein hydration layer density has earlier been observed at ambient conditions and ascribed to electrostriction. We calculate the pressure-induced protein mean surface charge density increment Δσ. Within the hydration layer, the higher fields due to Δσ lead to an additional water compression via electrostriction. The increment Δσ is considered as due to a mechanoelectric effect in protein molecules. The mean value of the effective mechanoelectric coefficient d is calculated and compared with piezoelectric coefficients of amino acids and their compounds.