Epidemiology and etiology of intracranial meningiomas: A review
Epidemiology and etiology of intracranial meningiomas: A review
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DOI：
10.1007/bf00165649
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发表时间：
1996-09-01
影响因子：
3.9
通讯作者：
Ligon, BL
中科院分区：
文献类型：
--
作者：
Bondy, M;Ligon, BL
脑膜瘤的发生率一直是相对较少报道的主题。基于医院的脑肿瘤系列研究表明，其发病率约占所有颅内肿瘤的20%;基于人群的研究表明，总发病率为2.3/100，000。虽然颅内肿瘤作为一个整体显示出男性比女性更高的患病率，脑膜瘤有2：1的女性对男性的比例。在高加索人和非洲人、非洲裔美国人和亚洲人之间，也注意到了某些差异。儿童脑膜瘤很罕见，与成人和其他儿童肿瘤不同;在婴儿中更罕见。已经确定了几个指示病因的特征，其中包括电离辐射、头部损伤、激素和其他受体结合位点、遗传因素和病毒。头部暴露于电离辐射的最常见来源是牙科放射检查。自1922年以来，头部创伤一直被认为是一个可能的风险因素，但最近的大型研究并不支持这种联系。有几个因素促使研究雌激素和孕激素作为脑膜瘤的危险因素。其他研究试图确定某些个体是否具有发展脑膜瘤的遗传倾向和/或病毒是否可能单独或与其他诱变剂一起作用，形成脑膜瘤。最有希望的研究是细胞遗传学的研究，未来阐明与22号染色体一个拷贝丢失相关的因素，这是脑膜瘤中发现的另一种现象，可能会导致筛查试验和基因治疗。
The frequency of meningiomas has been the topic of relatively few reports. Hospital-based brain tumor series indicate that the incidence is approximately 20% of all intracranial tumors; population-based studies indicate an overall incidence of 2.3/100,000. Although intracranial tumors as a whole show a higher prevalence in males than in females, meningiomas have a 2:1 female-to-male ratio. Between Caucasians and Africans, African-Americans, and Asians, certain differences also have been noted. Meningiomas in children are rare and differ from those in adults and other childhood tumors; they are even more rare in infants. Several features indicating etiologic factors have been identified, among which are ionizing radiation, head injury, hormones, and other receptor binding sites, genetic factors, and viruses. The most common source of exposure of the head to ionizing radiation is dental radiographic examination. Since 1922, head trauma has been considered a possible risk factor, but recent large studies do not support this link. Several factors have prompted studies of estrogens and progestogens as risk factors for meningiomas. Other studies have sought to determine if certain individuals have an inherited predisposition for developing a meningioma and/or if viruses, which may act alone or with other mutagens, figure into the formation of a meningioma. The most promising studies are those of cytogenetics, and future elucidation of factors associated with the loss of one copy of chromosome 22, another phenomenon that has been identified in meningiomas, may lead to screening tests and gene therapy.