Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.
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芳烃受体（AhR）参与小鼠调节性T细胞（Treg细胞）和产生白细胞介素17（IL-17）的辅助性T细胞（TH 17细胞）的分化，但其在人类T细胞分化中的作用尚不清楚。我们研究了AhR在人诱导Treg细胞（iTreg细胞）分化中的作用。我们发现AhR激活促进了CD 4 + Foxp 3 − T细胞的分化，后者通过颗粒酶B产生IL-10和控制应答T细胞。然而，在转化生长因子-β1存在下AhR的活化诱导Foxp 3 + iTreg细胞，其通过外核苷三磷酸二磷酸水解酶CD 39抑制应答T细胞。功能性Foxp 3 + iTreg细胞的诱导需要转录调节因子Smad 1和Aiolos的协调作用。因此，AhR是一个潜在的目标，通过它可以在人类自身免疫性疾病中诱导功能性iTreg细胞。
The aryl hydrocarbon receptor (AhR) participates in the differentiation of mouse regulatory T cells (Treg cells) and interleukin 17 (IL-17)-producing helper T cells (TH17 cells), but its role in human T cell differentiation is unknown. We investigated the role of AhR in the differentiation of human induced Treg cells (iTreg cells). We found that AhR activation promoted the differentiation of CD4+Foxp3− T cells, which produce IL-10 and control responder T cells through granzyme B. However, activation of AhR in the presence of transforming growth factor-β1 induced Foxp3+ iTreg cells, which suppress responder T cells through the ectonucleoside triphosphate diphosphohydrolase CD39. The induction of functional Foxp3+ iTreg cells required coordinated action of the transcriptional regulators Smad1 and Aiolos. Thus, AhR is a potential target through which functional iTreg cells could be induced in human autoimmune disorders.