Brain inflammation as a biomarker in epilepsy.
Brain inflammation as a biomarker in epilepsy.
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DOI：
10.2217/bmm.11.61
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发表时间：
2011-10
影响因子：
2.2
通讯作者：
Friedman A
中科院分区：
文献类型：
--
作者：
Vezzani A;Friedman A
实验和临床证据表明，慢性癫痫脑中特定炎症介质的合成增加，其同源受体上调，表明癫痫病灶中一些促炎症途径被激活。通过药物干扰特定促炎信号传导来抑制实验性癫痫发作，以及炎症途径受到干扰的转基因小鼠对癫痫发作的内在易感性变化的证据，有助于建立脑炎症在癫痫发作发病机制中起作用的概念。越来越多的证据还强调了受损大脑中产生的炎症过程可能参与癫痫的发展（即癫痫发生）。由于癫痫中的脑部炎症不仅仅是病理学的附带现象，而且可能涉及神经元过度兴奋、癫痫发作及其复发的机制，因此它可以被认为是疾病发展和严重程度的生物标志物，因此，只要开发出足够的非侵入性方法来检测和量化人类脑部炎症，就可以用于诊断、预后或治疗目的。
Experimental and clinical evidence have demonstrated the increased synthesis of specific inflammatory mediators, and the upregulation of their cognate receptors in the chronic epileptic brain, indicating that some proinflammatory pathways are activated in seizure foci. Inhibition of experimental seizures by pharmacological interference with specific proinflammatory signaling, together with evidence of changes in intrinsic susceptibility to seizures in transgenic mice with perturbed inflammatory pathways, was instrumental to establish the concept that brain inflammation has a role in the etiopathogenesis of seizures. Increasing evidence also highlights the possible involvement of inflammatory processes arising in the injured brain in the development of epilepsy (i.e., in epileptogenesis). Since brain inflammation in epilepsy is not a mere epiphenomenon of the pathology but is likely involved in the mechanisms underlying neuronal hyperexcitability, the onset of seizures and their recurrence, it might be considered as a biomarker of disease development and severity, and, as such, could be used for diagnostic, prognostic or therapeutic purposes, provided that adequate noninvasive methodologies are developed to detect and quantify brain inflammation in humans.
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DOI：
10.1093/brain/awq113
发表时间：
2010-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Irani SR;Bera K;Waters P;Zuliani L;Maxwell S;Zandi MS;Friese MA;Galea I;Kullmann DM;Beeson D;Lang B;Bien CG;Vincent A
通讯作者：
Vincent A
影响因子：
2.2
作者：
Holtman, L.;van Vliet, E. A.;Gorter, J. A.
通讯作者：
Gorter, J. A.
影响因子：
2.2
作者：
Hulkkonen, J;Koskikallio, E;Peltola, J
通讯作者：
Peltola, J
影响因子：
4.2
作者：
Bellander, BM;Singhrao, SK;Svensson, M
通讯作者：
Svensson, M
影响因子：
2.2
作者：
Friedman, Alon;Kaufer, Daniela;Heinemann, Uwe
通讯作者：
Heinemann, Uwe