Redistribution of synaptic efficacy between neocortical pyramidal neurons
Redistribution of synaptic efficacy between neocortical pyramidal neurons
复制标题
DOI：
10.1038/382807a0
复制
发表时间：
1996-08-29
期刊：
影响因子：
64.8
通讯作者：
Tsodyks, M
中科院分区：
文献类型：
--
作者：
Markram, H;Tsodyks, M
经验依赖性增强和突触强度抑制已被提出通过改变神经元之间传递的信号增益来帮助学习和记忆（1，2）。在这里，我们研究单个新皮层层5锥体神经元之间的突触可塑性，我们表明，增加突触反应，诱导的配对动作电位活动在突触前和突触后神经元，只观察到当突触输入发生在低频率。突触反应的这种频率依赖性增加是由于可用突触功效的重新分布而不是因为功效的增加而产生的。突触效能的重新分布可能代表了一种改变神经元之间传递的信号的内容而不是增益的机制。
EXPERIENCE-dependent potentiation and depression of synaptic strength has been proposed to subserve learning and memory by changing the gain of signals conveyed between neurons(1,2). Here we examine synaptic plasticity between individual neocortical layer-5 pyramidal neurons, We show that an increase in the synaptic response, induced by pairing action-potential activity in pre- and postsynaptic neurons, was only observed when synaptic input occurred at low frequencies. This frequency-dependent increase in synaptic responses arises because of a redistribution of the available synaptic efficacy and not because of an increase in the efficacy. Redistribution of synaptic efficacy could represent a mechanism to change the content, rather than the gain, of signals conveyed between neurons.