Circulating fibrocytes: cellular basis for NSF.
Circulating fibrocytes: cellular basis for NSF.
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DOI：
10.1016/j.jacr.2007.08.016
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Bucala, Richard
中科院分区：
文献类型：
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作者：
Bucala, Richard
自从循环纤维细胞作为外周血胶原生成细胞被发现以来，这一独特的细胞群的生理和病理作用一直在稳步增长。本文综述了纤维细胞的生物学特性，并讨论了纤维细胞在肾源性系统性纤维化发病机制中作用的证据。本文还讨论了可能的机制，即Gd可能影响纤维细胞的激活或运输特性，从而导致组织纤维化。
Since the discovery of the circulating fibrocyte as a collagen-producing cell of the peripheral blood, the physiologic and pathologic role of this unique cell population has grown steadily. The present review summarizes the known biology of fibrocytes and discusses evidence for their role in the pathogenesis of nephrogenic systemic fibrosis. Possible mechanisms by which gadolinium may influence the activation or trafficking properties of fibrocytes leading to tissue fibrosis are discussed.