Chromosome aberrations as a dosimetric technique for fission neutrons over the dose-range 0.2--50 rad.
Chromosome aberrations as a dosimetric technique for fission neutrons over the dose-range 0.2--50 rad.
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染色体畸变作为裂变中子剂量测定技术，剂量范围为 0.2--50 rad。
DOI：
10.1080/09553007814550181
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
G. Scarpa
中科院分区：
文献类型：
--
作者：
N. Vulpis;L. Tognacci;G. Scarpa
对文献的分析表明，在50rad以下的剂量范围内，关于应用于中子场的细胞遗传学剂量学的基本生物学参数缺乏数据。人的外周血淋巴细胞在体外暴露于平均能量为0.4 MeV的退化裂变中子谱。剂量范围为0.2-50rad，剂量率约为0.2或7rad/min。使用计算机程序对结果进行处理。双着丝粒诱导的实验数据和理论考虑都表明，一次多项式是最适合的剂量-反应函数。讨论了这些结果对细胞遗传学剂量学的影响。与相同范围内的250千伏X射线数据进行比较，得到了r.b.E.18.5+/-3.1。
An analysis of the literature shows a lack of data about basic biological parameters regarding cytogenetic dosimetry as applied to neutron fields, in the dose range below 50 rad. Human peripheral blood lymphocytes were exposed in vitro to a degraded fission neutron spectrum of mean energy 0.4 MeV. The dose-range was 0.2--50 rad delivered at a dose-rate of about 0.2 or 7 rad/min. The results were processed using a computer programme. Both experimental data for dicentric induction, and theoretical considerations indicate the first-order polynomial as the best fitting dose--response function. The implications of these results for cytogenetic dosimetry are discussed. A comparison with 250 kV X-ray data in the same range gives an r.b.e. of 18.5 +/- 3.1.